Visceral pain is a sort of pain, which is caused by activation of sore sensor in visceral organs when they get nociceptive stimulation. When visceral hyperalgesia occur, the variety of the sensitivity of nerve fibre, which controls the organ, is same as that of soma hyperalgesia, which takes place when skin hurt or inflammation. They both represent the trait of excess sensitivity. Come to light, visceral hyperalgesia is participated by peripheral mechanism and central mechanism. We have summarized the knowledge about central sensitization of visceral hyperalgesia in this article which consists of four sections. The first section sums up the conception and four traits of visceral pain. The second one summarizes the conception of visceral hyperalgesia, which is a phenomenon of threshold of pain decline or sensitivity of pain enhance in damnification, inflammation or persistent nociceptive stimulation, and three phenomena in the inflammatory visceral hyperalgesic experiments. The third part narrates the central sensitization of visceral hyperalgesia, which is comprised of seven segments. It also narrates the relations of the excitability amino acid, NMDA receptors, P substance, NK1 receptors, NO, Calcitonin Gene Related P eptide (CGRP), and extracellular signal-regulated kinases 1/2 (ERK1/2) to the central sensitization of visceral hyperalgesia. Last one, we sum up five others mechanisms of central hyperalgesia.
