Objective To compare the effect of etomidate and midazolam on heart rate and blood pressure during tracheal intubation in off-pump coronary artery bypass graft. Methods Sixty patients scheduled for coronary artery bypass graft surgery without cardiopulmonary bypass shunt were randomly and double-blindly divided into etomidate group (Group E,n=30) and midazolam group (Group M,n=30) based on the anesthetic used for induction.Electrocardiogram,systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR) and pulse oximetry saturation (SpO2) were measured and recorded continuously,as well as the value of rate-pressure product (RPP).The time used for tracheal intubation was also recorded.Results In Group M,compared with pre-tracheal intubation,the SBP and DBP of all patients decreased remarkably at the beginning of tracheal intubation (P<0.05).At 1 minute post-trachealintubation,the SBP,DBP and HR increased remarkably (P<0.01);meanwhile,the values of RPP were increased significantly than those at the beginning of tracheal intubation and pre-tracheal intubation (P<0.01).Compared with the values in Group E,at the beginning of tracheal intubation,the values of SBP and DBP in Group M were significantly decreased (P<0.05 and P<0.01,respectively),while the values of SBP,DBP and RPP at 1 minute after tracheal intubation were significantly increased (P<0.05 and P<0.01,respectively). Conclusions Compared with midazolam,etomidate used in anesthetic induction for coronary artery bypass graft surgery without cardiopulmonary bypass shunt may more effectively alleviate the cardiovascular responses to tracheal intubation.
