目的:观察光动力联合疗法治疗玫瑰痤疮的临床疗效。方法:选取2022年1月-2023年1月笔者医院就诊的200例玫瑰痤疮患者。采用随机数字表法分为研究组、对照组,各100例,并根据分型分为红斑毛细血管扩张型、丘疹脓疱型两个亚组。对照组给予外用克林霉素甲硝唑搽剂及医用愈肤生物膜治疗,研究组在对照组基础上给予5-氨基酮戊酸光动力疗法。比较两组治疗前、治疗4周后临床症状评分、皮损部位角质层含水量、经皮水丢失量(Trans epidermal water loss,TEWL)、血清白介素-17(IL-17)、干扰素-γ(IFN-γ)水平,记录两组疗效、蠕形螨转阴率、不良反应。结果:两种亚型研究组总有效率、蠕形螨转阴率均高于对照组(P<0.05);治疗4周后,两种亚型研究组临床症状评分均低于对照组(P<0.05);治疗4周后,两种亚型研究组角质层含水量均高于对照组,TEWL均低于对照组(P<0.05);治疗4周后,两种亚型研究组血清IL-17、IFN-γ水平均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:光动力联合疗法治疗红斑毛细血管扩张型、丘疹脓疱型玫瑰痤疮,可减轻临床症状,降低炎症因子表达,改善皮肤屏障功能,有效驱除蠕形螨,效果显著。
压力性尿失禁在我国人群中发病率较高,病程迁延不愈,易留下后遗症。本文查阅近5年相关文献发现,单一针刺疗法刺激量较小,对机体效应力弱,易于产生耐受。而针刺联合疗法可克服单一针刺治疗的这些缺点,高效、迅速的改善患者盆底肌肉的顺应性,促进盆底受损神经的恢复。本文就针刺联合中药、针刺联合灸法、针刺联合生物反馈电刺激、针刺联合盆底肌训练等针刺联合疗法进行评叙,以期拓宽压力性尿失禁的治疗思路,优化治疗方法。针对目前存在的治疗方法,笔者产生了一些思考,对不同患病人群提出了新的优化方向。Stress urinary incontinence has a high incidence rate among Chinese people, and the course of the disease is prolonged, which makes it easy to leave sequelae. This article reviewed relevant literature in the past 5 years and found that a single acupuncture therapy has a small stimulation amount, weak effect on the body, and is easy to develop tolerance. Acupuncture combined therapy can overcome the shortcomings of single acupuncture treatment, efficiently and quickly improve the compliance of pelvic floor muscles in patients, and promote the recovery of damaged pelvic floor nerves. This article reviews acupuncture combined with traditional Chinese medicine, acupuncture combined with moxibustion, acupuncture combined with biofeedback electrical stimulation, acupuncture combined with pelvic floor muscle training, etc., in order to broaden the treatment ideas and optimize the treatment methods for stress urinary incontinence. In response to the current treatment methods, the authors have generated some thoughts and proposed new optimization directions for different populations with different diseases.
