近年来,A型肉毒杆菌毒素(botulinum toxin type A,BTXA)在瘢痕的治疗中引起了广泛的讨论和关注,本综述旨在讨论近5年以来国内外学者对BTXA在各类瘢痕防治中的应用及研究。其中,BTXA在术后瘢痕的应用最为普遍,术后早期、更高剂量的注射方法能达到更好的疗效。BTXA对瘢痕疙瘩、增生性瘢痕具一定的治疗潜力,联合其他治疗方法能达到更好的治疗效果,其最常与局部皮质类固醇注射联合,及与微针、二氧化碳点阵激光、光动力联合治疗。总体而言,BTXA对各类瘢痕的疗效良好,不良反应少,但作用机制尚不明确,仍需进一步研究。
目的:探讨眼睑局部注射A型肉毒杆菌对于眼睑痉挛的效果。方法:收集2022年7月~2024年2月被我院确诊为特发性眼睑痉挛的患者资料,筛选出其中符合条件者共78例作为研究对象。所有受试者均给予眼睑局部多点A型肉毒杆菌毒素治疗。本次研究中,选取的观察指标包括药疗效果、维持时间与不良反应。结果:A型肉毒杆菌毒素眼睑局部注射后,观察到痉挛症状大多1~7天完全缓解,有效治疗率约为98.7%。药物疗效大多可以维持3~6个月左右,并且并发症少。结论:A型肉毒杆菌毒素对于特发性眼睑痉挛患者进行眼睑局部注射治疗效果显著而且副作用少见,值得在临床上推广使用。Objective: To investigate the effect of local injection of Botulinum Toxin Type A into eyelid for blepharospasm. Methods: Data of patients diagnosed with idiopathic blepharospasm in our hospital from July 2022 to February 2024 were collected, and a total of 78 eligible patients were selected as research objects. All subjects were treated with local eyelid multipoint Botulinum Toxin Type A. In this study, the observational indicators included therapeutic effect, maintenance time and adverse reactions. Results: The symptoms of spasmodic were completely relieved in 1~7 days with an effective rate of 98.7%. The effect usually lasts for 3~6 mouths with few complications. Conclusion: Botulinum Toxin Type A given by local injection on multiple sites is more effective than acupuncture and moxibustion in the treatment of idiopathic ocular and facial spasmodic.
