搜索到129892篇“ COMPOUND“的相关文章
Calculation of Compound Hazard Probability Using Convolution of Distributions
2025年
The hazard produced by natural phenomena on infrastructure and urban populations has been widely studied in the last 50 years. Researchers have recognised that the real danger posed by these phenomena depends on their extreme values. Most researchers focus on the extremes of natural phenomena considered in isolation, one variable at a time. However, what is relevant in hazard studies is coincident extremes of several climatic variables, i.e., the presence of compound extremes. The peak value of these extremes seldom coincides, but off-peak values located in the tail of the distributions are often concurrent and can lead to catastrophic events. What is essential in hazard studies is to calculate the probabilistic distribution of the extremes of coincident climatic variables. The presence of correlations between these variables complicates the problem. This paper presents a computationally efficient and robust mathematical methodology to solve the problem. The procedure is based on the convolution of the distributions of the climatic variables. Once the probabilistic distribution of the compound variables is found, it is possible to calculate the curves of the return period, which is the indicator of importance in hazard and risk studies. This compound Return Period is computed using the Statistics of Extreme Values. To illustrate the problem, the case of a cyclone landing close to a low-gradient coastal city is discussed, and its probability of flooding and recurrence period is calculated. We show that the failure to correctly model the correlation between variables can result in overestimating the Return Period curve, consequently increasing mitigation costs.
Luis Augusto Sanabria
Compound 3k治疗骨关节炎:调控氧化应激通路改善软骨细胞糖酵解的作用机制被引量:1
2025年
背景:骨关节炎现已被认为是一种代谢性疾病,既往研究表明糖酵解在骨关节炎的发生发展中起重要作用。Compound 3k作为一种新型糖酵解小分子抑制剂,具有抗炎及抗肿瘤等功效,因此可靶向糖酵解,有望为骨关节炎治疗提供新的思路。目的:基于缺氧诱导因子1α/活性氧的氧化应激通路探究Compound 3k在糖酵解过度活跃所导致的骨关节炎中的作用机制。方法:取对数生长期的ATDC5成软骨细胞,用10 ng/mL白细胞介素1β作用24 h诱导骨关节炎体外细胞模型,以CCK-8法检测不同浓度(0.25,0.5,1,2.5,5,10,15μmol/L)Compound 3k的细胞毒性,选出合适浓度进行后续实验。将软骨细胞随机分为对照组、模型组、治疗组,模型组以10 ng/mL的白细胞介素1β诱导,治疗组以Compound 3k预刺激2 h后与白细胞介素1β共培养,用CCK-8法检测各组细胞增殖情况;用ELISA试剂盒检测各组细胞炎症水平;用试剂盒检测各组细胞活性氧、细胞外乳酸脱氢酶及葡萄糖含量;qRT-PCR及Western blot检测相关炎症因子白细胞介素6、肿瘤坏死因子α及糖酵解相关基因葡萄糖转运蛋白1、甘油醛3-磷酸脱氢酶、单羧酸转运蛋白1和缺氧诱导因子1α的表达水平。结果与结论:①与对照组相比,模型组细胞增殖活性下降、糖酵解水平活跃,表现为细胞外乳酸脱氢酶含量增加(P<0.001),葡萄糖含量减少(P<0.001),相关炎症因子白细胞介素6(P<0.0001)及肿瘤坏死因子α(P<0.001),糖酵解相关基因葡萄糖转运蛋白1(P<0.001)、甘油醛3-磷酸脱氢酶(P<0.001)、单羧酸转运蛋白1(P<0.001)及缺氧诱导因子1α(P<0.001)的表达水平均上调,并伴随氧化应激,活性氧过量产生。②与模型组相比,Compound 3k的治疗有效提高细胞增殖活性,抑制过度活跃的糖酵解水平的同时,抑制了骨关节炎软骨细胞炎症(P<0.001)及糖酵解相关基因的表达(P<0.001),且抑制氧化应激,缺氧诱导因子1α的表达水平下调(P<0
郭素蓉曹士盛穆星彤杨青张娟
关键词:骨关节炎糖酵解氧化应激葡萄糖代谢白细胞介素1Β
复方黑参滴丸与复方黑参丸药效学实验比较研究
2025年
目的研究复方黑参滴丸(改进剂型)治疗慢性咽炎的药效学作用,并与传统制剂复方黑参丸(传统剂型)进行比较。方法选取健康Wistar大鼠60只,随机分为空白组、阳性对照组、治疗组。用1%角叉菜胶溶液注入每只大鼠的右后足爪皮下,测定致炎后1、2、3、4、5、6h每只大鼠的足跖肿胀厚度,计算每只大鼠的足跖肿胀率。通过大鼠的足趾肿胀实验模型,分别观察滴丸剂与丸剂两种剂型对角叉菜胶所致大鼠足跖肿胀的抑制作用;选取健康昆明种小鼠60只,随机分为空白组、阳性对照组、治疗组。连续灌胃给药4 d后,小鼠腹腔注射0.5%酚红溶液,30 min后处死小鼠,剥离出气管,用5%NaHCO_(3)溶液冲洗,取冲洗液,置于紫外分光光度计中,在546nm波长处测定吸光度,计算相对应的酚红浓度。通过小鼠的酚红祛痰实验,对比滴丸剂与丸剂两种剂型对实验性小鼠呼吸道酚红分泌量的影响差别。结果大鼠足趾肿胀实验结果表明:与空白实验组相比较,5个供试品液组(咽炎片组、复方黑参丸组,复方黑参滴丸低、中、高组)对角叉菜胶所引起的大鼠急性足跖肿胀均有显著的抑制作用。与复方黑参丸(传统剂型)组比较,复方黑参滴丸(改进剂型)高剂量组有显著性差异。小鼠酚红祛痰实验结果表明:与空白组相比较,5个供试品液组(复方黑参滴丸低、中、高3个剂量组、复方黑参丸组、咽炎片组)均能增加小鼠酚红分泌量。复方黑参滴丸(改进剂型)与复方黑参丸(传统剂型)对小鼠酚红分泌量的影响无显著性差异。结论复方黑参滴丸及复方黑参丸对实验动物均有明显的抗炎、祛痰作用。复方黑参滴丸与复方黑参丸的药理作用无显著性差异。
何静安晔张朝绅
关键词:抗炎作用祛痰作用
中国高温、干旱及其复合事件的研究进展和展望
2025年
干旱是全球最主要、影响最严重的气象灾害之一。随着全球变暖,干旱更易与高温同时发生,干旱与高温的正反馈过程导致极端事件持续更久、强度更强,形成高温干旱复合极端事件,对农业、生态环境等造成更为严重的影响。本文通过对中国高温、干旱及其复合事件研究进展的回顾,总结了中国高温、干旱及其复合事件的变化事实,并对影响中国高温、干旱的关键因子及物理机制进行了梳理;指出了当前研究存在的不足,并提出系统研究海温-陆面-海冰-大气多因子、多过程协同影响中国复合高温干旱事件的必要性;最后,对当前高温干旱的预测现状进行了简要回顾,指出在系统认识复合高温干旱事件发生发展机制的基础上,亟须发展动力-统计相结合的方法,以提升其预测水平。
祝亚丽刘洋孔祥慧王晓欣张梦琪洪晓玮陈活泼孙建奇
关键词:干旱
Compound hot drought events in the Mei-yu region:influences from polar and tropical regions
2025年
In the Mei-yu region,there has been noticeable increase in the occurrence of compound hot drought(CHD)events in recent years.However,the underlying causes of these occurrences remain poorly understood.To address this knowledge gap,we conducted a comprehensive study utilizing observational datasets,reanalysis datasets,and four numerical experiments to investigate the associated physical mechanisms.Our findings indicated that the prevalence of CHD events in the Mei-yu region is influenced strongly by two key factors:the decline in Barents Sea ice during February and the presence of a La Ni?alike pattern of sea surface temperature(SST)in April.The decline in Barents Sea ice generates an anomalous Rossby wave in the Arctic that propagates southeastward.The La Ni?a-like SST pattern regulates a Rossby wave over western America,propagating along the subtropical jet stream.These two Rossby waves induce northward movement and strengthened intensity of the subtropical westerly jet in East Asia.The local circulation patterns in the Mei-yu region are influenced by the position and intensity of the subtropical jet,leading to downward motion in accordance with the secondary circulation theory for high-altitude jet streams.Consequently,these local circulation patterns might contribute to occurrence of CHD events.Moreover,our analysis revealed that the impact of Barents Sea ice and the La Ni?a-like SST pattern can explain approximately two-thirds of the mild CHD events in the Mei-yu region,and that the influence of each is relatively independent.This research underscores influences of polar–tropical systems on climate extremes in eastern Asia.
Huixin LiBo SunZhongshi ZhangHuijun WangYeran ZhouJiani ZengBotao Zhou
国医大师周仲瑛复法理论辨治外感热病经验
2025年
总结首届国医大师周仲瑛教授复法理论治疗外感热病的经验,其特点为病势发展迅速,前后相贯;病理因素兼夹,互为因果;病位留滞传变,多脏相关;病情危重险恶,错杂反复。外感热病中复法的应用要点为辨识病理因素,分清先后主次;明确发病部位,注意邪正关系;厘清寒热虚实,以期阴阳平和;预测病势传变及时截断扭转。提出清气凉营,表里双解,开上、宣中、导下等外感热病常用复法,并以行气活血、扶正固脱法治疗厥、脱等外感重症。
郑志攀叶放
关键词:外感热病
Upgrading of 6–0 mm low rank high sulfur lignite by a compound dry cascade separation bed
2025年
In this paper,the effect of vibration intensity on the spatial distribution of sulfur content in bed particles was studied.The effects of vibration and airflow on the mechanical characteristics of particles were studied,the collision behavior mode of particles was determined,the spatial saltation law of particles was investigated,the spatial functional axis of beds was determined,and the saltation separation period of particles was determined.The test results show that:When separation bed provides inlet airflow velocity(U_(in)) is 2.55 m/s,the airflow distribution interval of I,II and III areas were U_(I)=2.55-2.57 m/s,U_(II)=1.33-1.35 m/s,U_(III)=0.35-0.38 m/s,respectively;when separation bed vibration amplitude (A)A=2.4-2.5 mm,separation bed vibration frequency (f) f=23-24 Hz,the desulfurization effect is the best.When vibration intensity (Γ)Γ=1.22,U_(in)=1.05 m/s,the particles have disordered contact and collision behavior.WhenΓ=14.89,U_(in)=3.18 m/s,the particles have a transition cataclastic collision.WhenΓ=5.80,U_(in)=2.55 m/s,the particles have directional collision behavior.It is determined that the OX axis is the transverse stable diffusion axis of the material,the OY axis is the longitudinal gradient transport axis of the material,and the OZ axis is the vertical density cascade distribution axis of the material.When separation time (T) T=0-10 s was the period of disorderly diffusion and mixing of particles,T=10-20 s was the period of directional migration and stratification of particles,and T=20-30 s was the period of cascade distribution and separation of particles.Finally,separation experiments conducted under optimal operating parameters demonstrated that the clean coal yield was 72.02%with a sulfur content of 0.98%.
Xiaodong YuDeqing Gan
基于复合病机论探讨国医大师周仲瑛原发性肝癌辨治思路
2025年
原发性肝癌(primarylivercancer,PLC)简称“肝癌”,发病隐匿,患者确诊时往往已处于疾病晚期,属于全身脏腑、气血津液紊乱的状态,病情复杂难辨。周仲瑛教授擅从整体辨治疾病,临证首重病机,提出急难病症的共性病机特征为复合病机。从复合病机论出发,探析周仲瑛教授辨治PLC的临床诊疗思路。认为多病理因素复合是PLC的病机特征,其中湿热瘀毒是PLC的基本病机,癌毒化生是PLC的病机转化关键环节;基于复合病机论治疗PLC可采用多法同用、复法制方的思路,主要包括扶正祛邪、调和五脏、通调气血津液、抗癌解毒治法。
补娟娟豆晓云孙萌叶放
关键词:原发性肝癌癌毒
复方磺胺间甲氧嘧啶研究进展
2025年
复方磺胺间甲氧嘧啶是由磺胺间甲氧嘧啶(SMM)与甲氧苄啶(TMP)组成的一种复方制剂,主要对猪弓形病、鸡球虫病、附红细胞体病有效。现有制备工艺主要有超微粉碎技术、固体分散技术和喷雾干燥技术,但是这些制备工艺生产的药物存在颗粒粒径过大、TMP水溶性差和口服给药吸收效果差等问题。乳酸TMP水溶性高,但是与碱性药物联用时易出现沉淀。近年来,为提高该制剂水溶性和生物利用度,已开展新型纳米工艺研究。但是尚无新型纳米复方制剂上市。本文阐述了复方磺胺间甲氧嘧啶的药代动力学特征,以定量反映药物在生物体内的动态变化规律,可根据药物在不同动物体内的不同半衰期,确定药物的给药剂量和时间间隔,从而为药物设计与评价方案的制定提供科学依据。通过药物代谢动力学研究,可优化药物治疗方案,进而提高治疗效果,以期达到提高该制剂生物利用度和改善药物水溶性差的目的,为新型药物的研发提供参考。
陆林林王娟李江于方凌周雅馨李杰航程富胜张继瑜
关键词:抗菌活性药物代谢动力学
复方利血平氨苯蝶啶在大鼠体内的药动学研究
2025年
目的研究复方利血平氨苯蝶啶中硫酸双肼屈嗪、氨苯蝶啶、氢氯噻嗪及利血平4种有效成分在大鼠体内的药动学。方法SD大鼠随机分为3组,分别单次灌胃给予3.6、10.8和32.4 mg·kg^(-1)复方利血平氨苯蝶啶,不同时间点采血后采用高效液相色谱-质谱(HPLC-MS)测定硫酸双肼屈嗪、氨苯蝶啶、氢氯噻嗪、利血平的血药浓度,并通过DAS软件计算药动学参数。结果单次灌胃给予3.6、10.8和32.4 mg·kg^(-1)复方利血平氨苯蝶啶后,大鼠血浆中硫酸双肼屈嗪的达峰时间(t_(max))分别为1.50、1.33、1.42 h,峰浓度(C max)分别为12.30、38.31、120.52μg·L^(-1);氨苯蝶啶的t_(max)分别为1.33、1.33、1.42 h,C max分别为20.93、67.36、168.64μg·L^(-1);氢氯噻嗪的t_(max)分别为2.00、2.00、1.75 h,C max分别为19.89、57.58、160.78μg·L^(-1);利血平在大鼠血浆中含量极低,仅在32.4 mg·kg^(-1)给药后1和1.5 h检测到微量。结论口服给予大鼠复方利血平氨苯蝶啶后,硫酸双肼屈嗪、氨苯蝶啶和氢氯噻嗪能够较快清除,且其口服吸收基本成线性,在线性范围内给药剂量越大,有效成分的吸收越好。
谢逸菲张雯张森宋俊科杨海光王守宝吕扬杜冠华
关键词:药动学血药浓度高效液相色谱-质谱联用

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崔景荣
作品数:183被引量:816H指数:17
供职机构:北京大学
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