2022年7月6日至2023年1月22日,意大利时装设计师艾尔莎夏帕瑞丽(Elsa Schiaparelli)回顾展将于法国巴黎装饰艺术博物馆(Musee des Arts Decoratifs)展出。展览将通过272件服装和饰品以及近250件绘画、雕塑、珠宝、香水、瓷器、海报等作品,集中展示艾尔莎·夏帕瑞丽如何在时尚与艺术之间构建富有创造力的“对话”
BACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products(AGEs),which induce tissue inflammation and oxidative damage.However,the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease(NAFLD)is unclear.AIM To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil population.METHODS In 305 individuals at baseline ELSA-Brasil,NAFLD-associated steatosis was classified by ultrasound hepatic attenuation.The participants were grouped according to the severity of steatosis:mild and moderate/severe pooled.The measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric detection.Serum AGE content and clinical and laboratory characteristics of the participants were compared between groups.The correlation between serum AGE levels and the grade of steatosis was analyzed.Logistic regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity.A P value<0.05 was considered statistically significant.RESULTS According to the steatosis severity spectrum in NAFLD,from mild to moderate/severe,individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome(63%vs 34%,P≤0.001),diabetes mellitus(37%vs 14%,P≤0.001),and high cholesterol levels(51%vs 33%,P<0.001).Moreover,individuals with increasing severity of steatosis presented increasing waist circumference,body mass index,systolic and diastolic blood pressure,fasting blood glucose,glycated hemoglobin,insulin,triglycerides,alanine aminotransferase,gamma-glutamyl transferase,C-reactive protein,and uric acid levels and lower high-density lipoprotein.Higher serum AGE content was present in the moderate/severe group of individuals than in the mild group(P=0.008).In addition,the serum AGE levels were correlated with the steatosis grade in the overall sample(rho=0.146,P=0.010).Logistic regression analysis,after adjusting for confoundin
Evelyn Nunes Goulart da Silva PereiraDaniela Polessa PaulaBeatriz Peres de AraujoMaria de Jesus Mendes da FonsecaMaria de Fátima Haueisen Sander DinizAnissa DaliryRosane Harter Griep