搜索到151982篇“ PATHOLOGICAL“的相关文章
苯酚在病理技术苏木精-伊红染色法中对病理切片质量的影响
2024年
目的探究苯酚在病理技术苏木精-伊红(HE)染色法中对病理切片质量的影响。方法选取2022年3月至2023年1月赣州市妇幼保健院纳入的80例实施病理诊断的患者作为研究对象,按照随机数字表法分为观察组与对照组,每组各40例。对照组病理切片采用常规HE染色,观察组病理切片在对照组的基础上联合苯酚染色。评估两组患者病理切片诊断准确率、病理切片质量。结果观察组病理切片诊断准确率为92.50%,高于对照组的病理切片诊断准确率(75.00%),差异有统计学意义(χ^(2)=4.501,P=0.034)。观察组病理切片质量优良率为100.00%,高于对照组病理切片质量优良率(85.00%),差异有统计学意义(χ^(2)=4.505,P=0.034)。结论苯酚应用于病理技术HE染色效果明显,可有效提高病理切片诊断准确率以及病理切片质量,为临床诊断和治疗相关疾病提供科学合理技术手段。
李红红廖林虹王茜黄丽娟
关键词:苯酚苏木精-伊红染色病理技术
胃肠道间质瘤的临床特点及病理学特点分析
2024年
目的探讨胃肠道间质瘤(GIST)的临床特点及病理学特点。方法选取75例胃肠道间质瘤患者为研究对象,采用回顾性分析法记录所有数据。统计分析胃肠道间质瘤的临床特征、病理数据、免疫组化检测结果、CT检查特征。结果75例胃肠道间质瘤患者中,年龄>50岁的患者占68.00%(51/75);存在腹部痛疼或肿胀不适的患者占42.67%(32/75);发生黑便、消化道出血等症状的患者占34.67%(26/75);发生腹部肿块的患者占22.67%(17/75)。发生腹部压痛感的患者占33.33%(25/75);能够检测到腹部肿块的患者占36.00%(27/75);经肠道检查发现肿块的患者占10.67%(8/75);无明显临床症状或阳性体征反应的患者占20.00%(15/75)。经实验室检查后证实:白蛋白或总蛋白下降的患者占20.00%(15/75)、便常规潜血形成的患者占38.67%(29/75)、血红蛋白降低的患者占41.33%(31/75)。75例胃肠道间质瘤患者中,病理分级为极低危险度的患者占10.67%(8/75),低危险度的患者占22.67%(17/75),中等危险度的患者占24.00%(18/75),高危险度的患者占42.67%(32/75)。胃肠道间质瘤细胞形态组织学特征为梭形或上皮样。75例胃肠道间质瘤患者中,CD117阳性表达率高达94.67%,CD34阳性表达率高达72.00%,部分患者神经元特异性烯醇化酶(NSE)、平滑肌肌动蛋白(SMA)、S-100、PGP915呈阳性表达。75例胃肠道间质瘤患者中,59例胃肠道间质瘤患者CT检查结果为膨胀生长,呈现为椭圆状或球形的肿块,其中28例患者CT形态呈分叶状。34例患者CT平扫肿块密度相对均匀的占29例,51例患者的病灶影像学显示有出血、囊变和不同程度坏死等病变,28例患者显示肿块病灶边界清晰,32例患者显示肿块边界模糊且与周边的相关脏器粘连。75例胃肠道间质瘤患者中均未发现病灶钙化。增强CT扫描结果显示,不均匀强化病例为50例,中度强化的病例为17例,轻度强化的病例为8例。结论通过观察并分析胃肠道�
程倩
关键词:胃肠道间质瘤病理学诊断CT检查病理特点
一体化智慧病理诊断平台设计与实现
2024年
目的:构建全自动化的智慧病理诊断平台,覆盖病理诊断全流程,提高病理诊断的准确性和效率。方法:采用微服务架构的自动化平台CUBE技术,实现病理信息系统与智慧病理系统的数据融合,构建病理切片数字化、上传、存储和临床信息获取,以及癌区预测和诊断报告生成无缝衔接的全自动化智慧病理诊断流程。结果:全自动化智慧病理诊断平台的应用显著提高了病理诊断的效率,减少了人工操作的成本。通过标准化的服务接口,平台简化了不同系统之间的对接过程,提高了医疗信息系统的整体效率。结论:全自动化智慧病理诊断平台为病理医生提供了强大的辅助诊断工具,展示了自动化和智能化在病理诊断领域的潜力。
卢征刘爱军宫彦婷
关键词:数据融合病理诊断
Covering corneal stromal lenticule for macular hole in pathological myopia
2024年
AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological myopia.METHODS:This was a prospective non-randomized series case study.Fourteen eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this study.All cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas tamponade.These cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were analyzed.RESULTS:All cases were successfully performed the surgery and the postoperative follow-up was completed.After surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence tomography.The reattachment of retina was achieved in all 6 eyes(100%,6/6)with MHRD.BCVA was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all cases.CONCLUSION:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary study.And it can effectively improve the visual function of patients.This new technique offers meaningful new ideas for treating refractory MH in pathological myopia.
Zi-Yan TangGang QiaoXiao-Juan ZhangLi-Jun XieQiang-Xing ZouChun-Mei HeLong ZhaoHua-Qing YangYu QuanKui CaoHui JiangYu-Kun He
肺结节性病变-肺腺癌病理新进展
2024年
肺结节性病变包括良性和恶性肺结节。肺腺癌是恶性肺结节中最常见的一种类型。肺腺癌包括前驱腺体病变、微浸润性腺癌、浸润性黏液腺癌和非黏液腺癌,病理学亚型不同,其手术方式及预后也不尽相同。目前认为肿瘤肺泡腔内播散及亚型中微乳头成分和实性成分的占比直接影响外科手术方式及预后。故本研究提出对于前驱腺体病变可以楔形肺切除;微浸润性腺癌可以亚肺叶切除;浸润性腺癌需肺叶切除加淋巴结清扫。即使是Ia期的肺腺癌患者,如果含有肺泡腔内播散、微乳头、胸膜侵犯成分亦推荐术后辅助治疗。
易伟强吴艺根伊雪
关键词:肺腺癌预后外科手术
Pathological and Etiological Aspects of Nephrotic Syndrome at the Niamey General Reference Hospital
2024年
Introduction: Studies have been conducted on nephrotic syndrome in Niger. The study aimed to determine the histological and etiological aspects of nephrotic syndrome. Patients and Method: This was a retrospective study from February 1st, 2018 to January 31st, 2024. All patients with nephrotic syndrome who underwent renal biopsy were included. Samples were analyzed at the anatomy-cytology pathology laboratory of the Faculty of Medicine in Dakar (Senegal). The variables studied included clinical, biological, histological and etiological characteristics. Data were analyzed using Excel 2013 and Epi-info 7.2.0 software. Results: The study included 119 patients with nephrotic syndrome. Prevalence of nephrotic syndrome was 11.24%. The male-to-female ratio was 2.25:1. The mean age at diagnosis was between 34.5 ± 18.84 years. Edema was the reason for admission in 40.34% of cases. The nephrotic syndrome was impure in 63.86% of cases. Nine histological lesions were identified. Focal and segmental glomerulosclerosis (40.09%), minimal change disease (23.53%), membranous nephropathy (13.45%), diabetic nephropathy (10.92%), membranous proliferative glomerulonephritis (3.36%), acute glomerulonephritis (3.36%), glomerular thrombotic microangiopathy (2.52%), non-IgA mesengial proliferative glomerulonephritis (1.68%) and amyloidosis (0.84%). Nephrotic syndrome was primary in 57.98% of cases. Secondary etiologies were dominated by diabetes (11.76%), followed by hepatitis B virus (9.24%), lupus, lymphoma, malaria, syphilis, cryoglobulinemia, sickle cell disease and HIV. Conclusion: Future studies should investigate the causes of glomerulopathy secondary to chronic tubulointerstitial lesions.
Djibrilla GaniSalamatou Amadou NiaouroOumarou Ali Diallo
m6A甲基化修饰非编码RNA调控病理性心脏重塑的作用被引量:1
2024年
背景:m6A甲基化修饰非编码RNA是病理性心脏重塑形成机制的研究热点,在心血管疾病的发生发展中起着重要作用。目的:总结m6A甲基化修饰非编码RNA对调控病理性心肌肥大、心肌细胞死亡、心肌纤维化与血管重塑等病理性心脏重塑主要过程的可能作用机制。方法:以“m6A甲基化修饰,非编码RNA,病理性心肌肥大,心肌细胞凋亡,心肌细胞焦亡,心肌细胞铁死亡,心肌纤维化,血管重塑”为中文主题词,以“m6A、non-coding RNA,pathological cardiac hypertrophy,cardiomyocyte apoptosis,cardiomyocyte pyroptosis,cardiomyocyte ferroptosis,myocardial fibrosis,vascular remodeling”为英文主题词,检索中国知网、PubMed、Web of Science数据库1974年1月至2023年4月发表的相关文献,对符合筛选标准的86篇文献进行综述。结果与结论:①m6A甲基化修饰是一种动态可逆的表观遗传修饰方式;②病理性心脏重塑主要包括病理性心肌肥大、心肌细胞死亡、心肌纤维化、血管重塑,m6A相关酶可调控病理性心脏重塑相关进程;③m6A甲基化修饰相关酶可通过多种非编码RNA与不同信号通路参与调控病理性心脏重塑过程,可作为心血管疾病新的潜在干预方式;④在病理性心脏重塑中,m6A甲基化修饰与非编码RNA之间的调控关系仍处于起步阶段,随着表观遗传学的发展,m6A甲基化修饰非编码RNA来调控病理性心脏重塑有望有新的发展。
尹功华徐若瑶张丽娟张一凡齐洁张钧
关键词:心肌细胞死亡血管重塑
载脂蛋白E在阿尔茨海默病病理过程中的病理机制研究进展
2024年
阿尔茨海默病(AD)是以认知功能减退为特征的老年人常见的神经系统变性疾病,是导致老年人痴呆最常见的病因。目前阿尔茨海默病发病机制尚不明确,尚无针对病因的治疗手段。载脂蛋白E(APOE)是目前唯一公认的AD风险基因,其编码的ApoE蛋白在β淀粉样蛋白(Aβ)沉积、tau蛋白的过度磷酸化和神经炎症反应等AD病理发生过程中起到重要作用。本文就ApoE的结构、功能及其在AD发生的病理过程中的作用进行综述,为寻找AD新的干预靶点提供思路和方向。
马艺迅侯婷婷(综述)杜怡峰(审校)
关键词:阿尔茨海默病载脂蛋白E病理机制
病理组织结核分枝杆菌阳性患者临床及病理特征分析
2024年
目的 探讨病理组织结核分枝杆菌(Mycobacterium tuberculosis,MTB)阳性患者的临床及病理特征,为疑似结核病患者的诊断提供参考。方法 回顾性分析2020-01/2022-10月作者医院科室疑似MTB感染1130例患者资料,采用金胺O荧光染色法、分子生物学检测法确诊MTB感染患者235例,分析患者性别、年龄、组织种类、标本类型和病理特征与病理组织MTB阳性的相关性。结果 235例病理组织MTB阳性患者中,男性164例,占比69.79%,女性71例,占比30.21%,男性感染者占比显著高于女性;未成年3例,占比1.28%,成年232例,占比98.72%,以成年感染者为主。235例MTB阳性的病例中,以肺组织(107例,45.53%),淋巴结组织(37例,15.74%)和骨与关节组织(25例,10.64%)最为常见。手术标本MTB阳性率50.64%,显著高于穿刺标本的49.36%(χ^(2)=9.993,P=0.002)。肉芽肿病变标本MTB阳性率84.68%,显著高于非肉芽肿病变标本的15.32%(χ^(2)=29.510,P<0.001)。结论 对于病理组织MTB感染的患者,男性、成年、肺、淋巴结和骨与关节组织等因素有助于结核病的组织病理学诊断;而手术标本相对于穿刺标本、肉芽肿病变相对于非肉芽肿病变MTB阳性率高。
徐宝卿欧阳小娟张方琪
关键词:结核分枝杆菌病理组织肉芽肿
Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence
2024年
Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin resistance.Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and atherosclerosis.However,it remains unclear whether vaspin exerts specific effects on pathological cardiac hypertrophy.Methods:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko mice.Rapamycin was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce hypertrophy.Human vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic studies.Results:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ISO.Conversely,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and senescence.Furthermore,vaspin significantly potentiated the ISO-induced decrease in autophagy.Both rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated cardioprotection.Moreover,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and NRVMs.Our data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination degradation.Conclusion:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hypertrophy.
Haiying RuiHuaxiang YuDan ZouKai ChiPing XuXiaoshuai SongLulu LiuXuting WuJinxin WangLi Xue
关键词:UBIQUITINATIONVASPIN

相关作者

金娟
作品数:163被引量:150H指数:7
供职机构:浙江省人民医院
研究主题:特发性膜性肾病 自噬 糖尿病肾病 足细胞 PODOCYTE
魏栋
作品数:32被引量:83H指数:6
供职机构:江苏省人民医院
研究主题:垂体瘤 鼻腔 显微手术 微创手术 内镜辅助
李俊漾
作品数:9被引量:18H指数:2
供职机构:南京军区南京总医院
研究主题:神经内镜 CLINICAL STUDIES PATHOLOGICAL MENINGIOMA
何强
作品数:345被引量:325H指数:10
供职机构:浙江省人民医院
研究主题:血液透析 自噬 特发性膜性肾病 糖尿病肾病 足细胞
吴晶涛
作品数:181被引量:824H指数:14
供职机构:江苏省苏北人民医院
研究主题:磁共振成像 体层摄影术 X线计算机 CT表现 能谱CT