搜索到1168篇“ THIADIAZOLE“的相关文章
噻二唑衍生物的制备及性能评价
2024年
针对现有噻二唑衍生物制备工艺中废水化学需氧量(COD)极高的问题,探索以去离子水替代乙醇作为反应溶剂,并引入相转移催化剂促进固-液两相反应,开发了制备噻二唑衍生物的绿色环保新工艺;进而,采用红外光谱、液相色谱、质谱等手段对新工艺合成的产物进行了结构表征,采用铜片腐蚀试验和四球试验评价了合成产物的金属腐蚀抑制性能、极压性能和减摩性能。结果表明:采用新工艺合成产物过程中产生的废水COD为2000 mg/L,与传统工艺产生的废水COD(700000 mg/L)相比显著降低,说明新工艺符合绿色环保要求;采用传统工艺和新工艺分别合成了2,5-双(叔壬基二硫代)-1,3,4-噻二唑,其金属腐蚀抑制性能、极压性能、减摩性能相当,且优于市售噻二唑衍生物类金属减活剂T561。
李团乐刘玉峰张峻凡王俊明薛卫国安文杰吕会英
关键词:合成工艺废水化学需氧量相转移催化剂极压性能
新型含酰胺基硫脲结构1,3,4-噻二唑衍生物的合成及其抗菌活性
2024年
酰基硫脲结构化合物具有多种生物活性。以噻二唑胺为原料,经卤代、肼解生成酰肼,再与不同取代的苯甲酰基异硫氰酸酯反应合成10个新型含酰胺基硫脲结构的1,3,4-噻二唑衍生物(9a~9j)。所有化合物的结构经IR、~1H NMR和HR-MS(ESI)表征。采用牛津杯法对其进行抗菌活性筛选,结果表明:9a~9j对哈氏弧菌活性存在不同程度的抑制作用,其中9d抗菌活性最好,抑菌圈直径为15.74±0.26 mm。
梁馨文高田田邱敏胡继亮刘强张建龙吴玉宇苏子钦陈超曹联攻刘玮炜
关键词:异硫氰酸酯抗菌活性哈氏弧菌
探索性有机化学实验教学——以2-氨基-5-乙基-1,3,4-噻二唑的合成为例
2024年
有机化学实验是制药工程专业重要的基础课之一,既是对有机化学理论课的补充,又是学习药学专业课的基础。本文以氨基硫脲和丙醛为原料,通过改变溶剂、氧化剂种类、反应温度、反应时间及反应物投料比筛选出最优反应条件,从而提高2-氨基-5-乙基-1,3,4-噻二唑的产率。通过本次实验,不仅有利于学生巩固理论知识,提高实验动手能力,培养学生热爱化学,热爱科研,激发探索性思维具有重要的作用。
张琪朱亦杭李彤郑斌
关键词:氨基硫脲有机化学实验实验教学4-噻二唑
1,3,4-噻二唑衍生物的合成研究进展
2023年
含有1,3,4-噻二唑结构的化合物是许多药物及活性分子的重要中间体,具有抗癌、抗炎及镇痛以及抗菌等广泛的生物活性。近年来,1,3,4-噻二唑衍生物的合成研究得到了广泛的关注,基于1,3,4-噻二唑母核的分子被大量合成并应用于生物活性筛选。根据反应原料的差异,对1,3,4-噻二唑衍生物的合成研究进展进行综述,以期为相关的研究工作提供借鉴。
李元慈王妍姗库荣荣仝红娟
关键词:噻二唑1,3,4-噻二唑
Design of New Thiadiazole Derivatives with Improved Antidiabetic Activity
2023年
Diabetes is a serious, long-term (or chronic) disease that occurs when a person’s blood sugar levels are high because their body cannot produce enough insulin, or does not produce enough insulin or that it cannot effectively use the insulin it produces. According to the literature, this disease has several causes, but certain types of diabetes such as type 2 diabetes are most closely linked to a metabolic disorder due to abdominal obesity. Thus, the number of individuals with type 2 diabetes is increasing. It is with this in mind that we work to improve human health. The aim of this study is to design new derivatives of 1,3,4-thiadiazole with improved antidiabetic activity by the mathematical model of multiple linear regression (MLR) established previously. The analysis of the effect on the substituents influencing the antidiabetic activity, fourteen (14) new molecules coded CDTH were generated and presenting values of the potential of inhibitory concentration higher than that of the base compound (pIC50 = 2.526). But thirteen (13) of these new compounds belong to the domain of applicability of the MLR model established previously. In addition, the thermodynamic quantities of formation formed at 298K have been calculated. Lipinski’s rule and pharmacokinetic properties proved that five (5) (TH4, TH9, TH10, TH13 and TH14) new molecules can be used as diabetes medicine.
Chiépi Nadège Dominique DouGeorges Stéphane DembeleMamadou Guy-Richard KoneNanou Tiéba TuoFandia KonateAdama NiarePanaghiotis KaramanisNahossé Ziao
关键词:DESIGN
Carbazolebis(thiadiazole)-core based non-fused ring electron acceptors for efficient organic solar cells被引量:1
2023年
Non-fused ring electron acceptors(NFREAs)have a broad application prospect in the commercialization of organic solar cells(OSCs)due to the advantages of simple synthesis and low cost.The selection of intermediate block cores of non-fused frameworks and the establishment of the relationship between molecular structure and device performance are crucial for the realization of high-performance OSCs.Herein,two A-D-A’-D-A type NFREAs namely CBTBO-4F and CBTBO-4Cl,constructed with a novel electron-deficient block unit N-(2-butyloctyl)-carbazole[3,4-c:5,6-c]bis[1,2,5]thiadiazole(CBT)and bridging unit 4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b:3,4-b’]dithiophene(DTC)coupling with different terminals(IC-2F/2Cl),were designed and synthesized.The two NFREAs feature broad and strong photoresponse from 500 nm to 900 nm due to the strong intramolecular charge transfer characteristics.Compared with CBTBO-4F,CBTBO-4Cl shows better molecular planarity,stronger crystallinity,more ordered molecular stacking,larger van der Waals surface,lower energy level and better active layer morphology,contributing to much better charge separation and transport behaviors in its based devices.As a result,the CBTBO-4Cl based device obtains a higher power conversion efficiency of 10.18%with an open-circuit voltage of 0.80 V and a short-circuit current density of 21.20 mA/cm^(2).These results not only demonstrate the great potential of CBT,a new building block of the benzothiazole family,in the construction of high-performance organic conjugated semiconductors,but also suggest that the terminal chlorination is an effective strategy to improve device performance.
Yongjie CuiPeipei ZhuXinxin XiaXinhui LuXunfan LiaoYiwang Chen
2,5-Dimercapto-1,3,4-Thiadiazole(DMCT)-Based Polymers for Rechargeable Metal-Sulfur Batteries被引量:1
2023年
Organosulfur materials are a sustainable alternative to the present-day layered oxide cathodes in lithium-based batteries.One such organosulfur material that was intensely explored from the 1990s to early 2010s is 2,5-dimercapto-1,3,4-thiadiazole(DMCT).However,research interest declined as the electrode reactions with DMCT were assumed to be too sluggish to be practical.Armed with the advances in metal-sulfur batteries,we revisit DMCT-based materials in the form of poly[tetrathio-2,5-(1,3,4-thiadiazole)],referred to as pDMCT-S.With an appropriate choice of electrode design and electrolyte,pDMCT-S cathode paired with a Li-metal anode shows a capacity of 715 mA h g^(-1)and a Coulombic efficiency of 97.7%at a C/10 rate,thus quelling the concerns of sluggish reactions.Surprisingly,pDMCT-S shows significantly improved long-term cyclability compared to a sulfur cathode.Investigations into the origin of the stability reveals that the discharge product Li-DMCT in its mesomeric form can strongly bind to polysulfides,preventing their dissolution into the electrolyte and shuttling.This unique mechanism solves a critical problem faced by sulfur cathodes.Encouragingly,this mechanism results in a stable performance of pDMCT-S with Na-metal cells as well.This study opens the potential for exploring other organic materials that have inherent polysulfide sequestering capabilities,enabling long-life metal-sulfur batteries.
Amruth BhargavArumugam Manthiram
关键词:2,5-DIMERCAPTO-1,3,4-THIADIAZOLE
噻二唑衍生物润滑油添加剂研究进展
2023年
综述了近年来噻二唑衍生物润滑油添加剂的研究进展。主要介绍了含黄原酸结构的噻二唑衍生物添加剂、含二硫键结构的噻二唑衍生物添加剂、硼酸酯(盐)类噻二唑衍生物添加剂、含酰胺结构的噻二唑衍生物添加剂、噻二唑希夫碱添加剂、含酯或醚结构的噻二唑衍生物添加剂等一系列单一噻二唑润滑油添加剂。此外,还介绍了纳米颗粒与噻二唑衍生物的复合润滑油添加剂,该类复合润滑油添加剂能够显著提高润滑油基础油的摩擦性能。提出了制备油酸型噻二唑衍生物润滑油添加剂、噻二唑类离子液体润滑油添加剂及噻二唑纳米微粒润滑油添加剂的展望。
宋吉亮李宬学王娇代岩
关键词:润滑油添加剂抗磨减摩抗氧化极压性能
噻二唑衍生物对盐酸溶液中碳钢的缓蚀性能研究
2023年
为进一步探究碳钢缓蚀性能的提升路径,通过有机合成方法制备噻二唑衍生物,对盐酸溶液中碳钢的缓蚀性能展开研究,依次通过失重实验、阻抗谱分析和极化曲线等环节,印证了本次制备的噻二唑衍生物型缓蚀剂在缓蚀效果方面的优势作用。从实验测试效果来看,本次制备的噻二唑衍生物型缓蚀剂具有相对较优的缓蚀性能,具有潜在的应用价值。
李秀峰张保利
关键词:碳钢缓释性能
含5-巯基-1,3,4-噻二唑磺胺衍生物的合成
2023年
1,3,4-噻二唑核是最重要的杂环核之一,是许多天然产物和药物的共同特征。以1,3,4-噻二唑为起始原料,经卤代、酰化及水解反应合成了7种未见报道的新型5-巯基-1,3,4-噻二唑磺胺衍生物,利用红外光谱、核磁共振氢谱和高分辨质谱表征了化合物的结构;新合成化合物在丰富该类化合物的同时,也为1,3,4-噻二唑衍生物的合成提供了参考。
吴杨全吴杨全高田田邱敏梁馨文刘玮炜
关键词:1,3,4-噻二唑磺胺

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胡波
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康智慧
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