A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4（5H）-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data： monoclinic system,space group P21 /c,a = 8.423（8）,b = 19.596（16）,c = 8.770（8）,β = 107.750（12）°,V = 1379（2）3,Z = 4,F（000） = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections（Rint = 0.0782） and 2428 observed ones（I 2σ（I））.
Compound 1, N-methyl-N-（（2-（p-tolyl）quinolin-4-yl）methyl）aniline （C24H22N2）, as a potential drug for the treatment of acid-related diseases has been synthesized via palladium- catalyzed intramolecular hydroarylation. The compound was characterized by MS and NMR spectra. Meanwhile, the crystal of I was obtained and determined by X-ray single-crystal diffrac- tion. Crystal data： triclinic system, space group P1, a = 5.548（5）, b = 11.545（10）, c = 14.546（12）A, a = 90.427（15）, β = 90.727（14）, γ = 101.099（16）°, V= 914.1（13） A3, Z = 2, F（000） = 360, Dc = 1.230 g/cm3,μ = 0.072 mm-1, R = 0.0564 and wR = 0.1616 for 9768 independent reflections （Rint = 0.0447） and 3003 observed ones （I 〉 2σ（I））.
