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国家重点基础研究发展计划(2011CB911001)

作品数:1 被引量:5H指数:1
发文基金:国家自然科学基金国家重点基础研究发展计划更多>>
相关领域:生物学机械工程更多>>

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The effect of cigarette smoke extract on thrombomodulinthrombin binding: an atomic force microscopy study被引量:5
2012年
Cigarette smoking is a well-known risk factor for cardiovascular disease. Smoking can cause vascular endothelial dysfunction and consequently trigger haemostatic activation and thrombosis. However, the mechanism of how smoking promotes thrombosis is not fully understood. Thrombosis is associated with the imbalance of the coagulant system due to endothelial dysfunction. As a vital anticoagulation cofactor, thrombomodulin (TM) located on the endothelial cell surface is able to regulate intravascular coagulation by binding to thrombin, and the binding results in thrombosis inhibition. This work focused on the effects of cigarette smoke extract (CSE) on TM-thrombin binding by atomic force microscopy (AFM) based single-molecule force spectroscopy. The results from both in vitro and live-cell experiments indicated that CSE could notably reduce the binding probability of TM and thrombin. This study provided a new approach and new evidence for studying the mechanism of thrombosis triggered by cigarette smoking.
WEI YuJieZHANG XueJieXU LiYI ShaoQiongLI YiFANG XiaoHongLIU HuiLiang
关键词:THROMBINTHROMBOMODULINAFMPROTEIN-PROTEININTERACTION
An Aptamer Based Platform for Capture and Release of Circulating Tumor Cells
Circulating tumor cells(CTC)are rare cancer cells detached from solid tumors and circulated in peripheral bloo...
Li XuLibo ZhaoXiaohong Fang
关键词:CIRCULATINGTUMORAPTAMERNANOWIRES
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