Hypoxia is a disorder in which the tissues are not oxygenated adequately.The lack of oxygen may cause irreversible damage to the major organs such as the brain,heart and lungs.In severe cases,coma,seizures,and death may happen.In addition to the routine medication,acupuncture.treatment has been applied as a complementary treatment to counter hypoxia.In this paper,the optical fiber acupuncture needle was fabricated using the optical fiber imbedding into the metal capillary tube with needle tip,therefore made it easy to insert into the body for the laser treatment.The laser optical fiber needle treatment to the ST36 acupoint conducted with the laser.irradiation intra body.The normobaric hypoxia tolerance test results in mice show that the optical fber needle treatment to the ST36 acupoint with laser acupuncture appears to improve the tolerance to hypoxia.The mice treated with laser acupuncture expressed high level of IL-1βin serum.Our results suggest that laser optical fiber needle acupuncture may serve as a potential treatment for hypoxia.
Two kinds of Nb-doped silica fibers, an NbCl5-doped fiber and an Nb205-doped fiber, are fabricated and char- acterized in this Letter. First, the refractive index profiles of both fibers are obtained, and then their Raman spectra are measured with 785 nm exciting light. The Nb-doped fibers＇ Raman spectra are compared with a conventional GeO2-doped single-mode silica fiber that is prepared with the same method and under the same conditions. As a result, the Raman gain coefficients of the Nb-doped silica fiber core are obtained. The exper- imental results show that Nb2O5 doping can enhance the Raman scattering intensity of the optical fibers.
Purpose:This work focused on the investigation the hyperthermia performance of the carboncoated magnetic particles(CCMPs)in laser-induced hyperthermia.Materials and methods:We prepared CCMPs using the organic carbonization method,and then characterized them with transmission electron microscopy(TEM),ultraviolet-visible(UV-Vis)spectrophotometry,vibrating sample magnetometer(VSM)and X-ray di®raction(XRD).In order to evaluate their performance in hyperthermia,the CCMPs were tested in laser-induced thermal therapy(LITT)experiments,in which we employed a fully distributedfiber Bragg grating(FBG)sensor to profile the tissue's dynamic temperature change under laser irradiation in real time.Results:The sizes of prepared CCMPs were about several micrometers,and the LITT results show that the tissue injected with the CCMPs absorbed more laser energy,and its temperature increased faster than the contrast tissue without CCMPs.Conclusions:The CCMPs may be of great help in hyperthermia applications.
Shupeng LiuNa ChenFufei PangZhengyi ChenTingyun Wang
The optical fiber nanoprobe is prepared using spark fused taper and acid corrosion methods. With 3-aminopropyltrimethoxysilane coupling, gold nanoparticles are solidified onto the surface of fiber optic and then the optical fiber sensor is prepared using the surface-enhanced Raman spectroscopy （SERS） measurement of the cell solution. The SERS of the esophageal cancer cell solution is measured by direct detection and fiber detection methods. Similar results are obtained by both detection methods. SERS measurement of tissues and organs is done using the optical fiber sensor.
