Linear diribonucleoside phosphotriester is an important intermediate for synthesizing biologically important compounds, such as cyclic bis（3＇-5＇） diguanylic acid （c-di-GMP） and its analogues. Atropisomerism of diastereomers generated by the chiral center of the P atom, which results in the doubling of signals in 31p NMR. The data of 31p NMR at different temperature are presented, and thereafter the reason is discussed.
Lu-Xin NaXu-Lin SunMeng WangKun-Feng LiLei XingZhuo ChenZhu GuanZhen-Jun Yang
