The unique properties of paramagnetic nanoscale metal-organic frameworks provide them with high potential as key probes and vectors in the next generation of biomedical applications.To increase the nanoparticle targeting at the tumor site,the grafting of Mn(Ⅱ)-dpa (dpa =di(picolyl)amines) on oxide nanoparticles (SiO2) is proposed.The new Mn(Ⅱ)-dpa-grafted silica nanoparticles can enhance the MR imaging area in cancer tissues and perturb the Ca2+-loaded mitochondria swelling.Experimental results indicate the cancer cells may be targeted through possible intracellular Ca2+ signaling mitochondria accumulating in vivo.
CHEN QiuYun1,WANG LingYun1,ZHANG LiRong2,GUO WenJie3 & GAO Jing3 1School of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,China 2Department of Radiology,the Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China 3School of Pharmacy,Jiangsu University,Zhenjiang 212013,China
