INTRODUCTION Microparticles （MPs） were increased in patients with coronary heart disease （CHD）,with the subtypes and quantity of MPs variate in different types of CHD.There were emerging reports indicating that MPs may play important roles in the pathogenesis of CHD.Here in this review we summarized the pro-inflammation,pro-coagulation effects of MPs,as well as their impacts on endothelial function and angiogenesis.MPs have the potential of being powerful diagnostic biomarkers and therapeutic tools in CHD patients in the future.
Background There are patients who underwent emergency coronary angiography （CAG） but did not receive percutaneous coronary intervention （PCI）. The aim of this study was to analyze these reasons. Methods This is a single-center retrospective study. We recruited 201 consecutive patients who received emergency CAG but did not receive PCI. To investigate the value of the Global Registry of Acute Coronary Events （GRACE） score in predicting PC1 possibilities in non-ST segment elevation acute coronary syndrome （NSTE-ACS） pa- tients, we recruited 80 consecutive patients who presented with NSTE-ACS and received emergency CAG as well as emergency PC1. Re- sults Among the 201 patients who received emergency CAG but did not receive PCI, 26% patients had final diagnosis other than coronary heart disease. In the patients with significant coronary artery stenosis, 23 patients （11.5%） were recommended to coronary artery bypass grafting （CABG）, one patient （0.5%） refused PCI; 13 patients （6.5%） with significant thrombus burden were treated with glycoprotein IIb/IIIa receptor antagonist; 74 patients （36.8%） were treated with drug therapy because no severe stenosis （〉 70%） was present in the crime vessel. Moreover, 80 of the 201 patients were presented with NSTE-ACS （excluding those patients with final diagnosis other than coronary heart disease, excluding those patients planned for CABG treatment）, referred as non PCI NSTE-ACS. When comparing their GRACE scores with 80 consecutive patients presented with NSTE-ACS who received emergency CAG as well as emergency PCI （referred as PCI NSTE-ACS）, we found that PCI NSTE-ACS patients had significantly higher GRACE scores compared with non PCI NSTE-ACS patients. We then used Receiver Operator Characteristic Curve （ROC） to test whether the GRACE score is good at evaluating the possibilities of PCI in NSTE-ACS patients. The area under the curve was 0.854 ~ 0.030 （P 〈 0.001）, indicating good predictive value. Furthermore, we analyze
