国家自然科学基金(30960511)
- 作品数：1 被引量：7H指数：1
- 相关作者：吴艳玲宛莹廉丽花南极星更多>>
- 相关机构：延边大学更多>>
- 发文基金：国家自然科学基金更多>>
- 相关领域：医药卫生更多>>
- Betulinic acid exerts anti-fibrosis activity via regulating TLR4/NF-κB signaling and induces the apoptosis of activated hepatic stellate cells
- OBJECTIVE The purpose of the study was to investigate the anti-fibrosis mechanism of betulinic acid (BA), an a...
- WAN YingNAN Ji-xingWU Yan-lingLIAN Li-huaXIE Wen-xueLI XinOUYANG Bing-qingBAI TingLI QianYANG Ning
- 关键词：HSC-T6HEPATICFIBROSISTHIOACETAMIDE
- Effects of YC-1 on apoptosis of hepatic stellate cells
- OBJECTIVE To study the effects and mechanisms of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole(YC-1) ...
- OUYANG Bing-qingWU Yan-lingNAN Ji-xing
- 关键词：YC-1APOPTOSISHEPATICCELLSΑ-SMA
- Thymoquinone down-regulation lipopolysaccharide-induced TLR4 signaling via suppressing nuclear factor-κB activation in hepatic stellate cells
- OBJECTIVE Thymoquinone (TQ) is the major active compound derived from the medicinal Nigella sativa.It has been...
- BAI TingWU Yan-lingLIAN Li-huaNAN Ji-xing
- 关键词：THYMOQUINONEHEPATIC
- 虎眼万年青通过抑制CYP2E1和HIF-1α保护对乙酰氨基酚诱导的急性肝损伤(英文)被引量：7
- 2012年
- 目的:通过对乙酰氨基酚体内体外实验建立急性肝损伤模型,观察虎眼万年青总皂苷的肝保护作用。方法:体内实验,小鼠预先口服给予虎眼万年青总皂苷(300,200,100mg·kg-1)或N-乙酰-L-半胱氨酸(300mg·kg-1)3次,每次间隔24小时,末次给药后2小时腹腔注射对乙酰氨基酚。体外实验,张氏肝细胞培养在含有虎眼万年青(50,100,200mg·mL-1)或N-乙酰-L-半胱氨酸(10mmol·L-1)的培养基中,同时加入对乙酰氨基酚(10mmol·L-1)培养24小时。结果:虎眼万年青总皂苷在对乙酰氨基酚诱导肝损伤12小时后具有较强的肝保护作用,抑制了血清中谷草转氨酶和谷丙转氨酶的活性,减少了脂质过氧化物的生成,提高了过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性,抑制了细胞凋亡蛋白酶caspase-3和缺氧诱导因子-1α的表达。体外实验结果显示虎眼万年青总皂苷显著减少了对乙酰氨基酚代谢过程中关键酶细胞色素P4502E1的活性及环氧化酶2的表达。结论:虎眼万年青总皂苷对对乙酰氨基酚诱导的肝损伤具有保护作用其肝保护作用机制可能与抗氧化,抑制细胞色素P4502E1的活性和减少缺氧诱导因子1α的生成有关。
- 宛莹吴艳玲廉丽花南极星
- 关键词：虎眼万年青对乙酰氨基酚细胞色素P4502E1缺氧诱导因子-1Α
- 25-OCH3-PPD triggers anti-fibrosis activity via c-FLIP-mediated NF-κB activation on activated t-HSC/Cl-6 cells
- 25-OCH3-PPD is a dammarane-type triterpene sapogenin isolated from the roots, leaves and seeds of P.notoginsen...
- WU Yan-lingWAN YingOUYANG Bing-qingBAITingNAN Ji-xing
- 关键词：ANTI-FIBROSISC-FLIPNF-ΚB
