Background Arterial stiffness is well known as an important risk factor for coronary artery disease.In this study,we aimed to investigate the association between carotid-ankle pulse wave velocity （caPWV） and risk of coronary artery disease （CAD）,and the interaction between pulse wave velocity （PWV） and other potential risk factors of CAD.Methods A community-based cross-sectional study was conducted for subjects living in Beijing,China.We collected 213 subjects with coronary artery disease and 1 266 subjects without CAD between September 2007 and January 2009 in a community center of Beijing.A multivariate Logistic regression analysis was carried out to assess the odds ratios of factors related to CAD.Results We found CAD subjects were more likely to have a higher body massindex （BMI）,fasting glucose,uric acid,low-density lipoprotein （LDL） cholesterol,high-sensitivity Creactive protein （hs-CRP）,carotic-femoral pulse wave velocity （cfPWV） and caPWV （P ＜0.05）,and CAD subjects had a significantly lower HDL cholesterol levels （P ＜0.05）.Moreover,the proportion of hypertension in CAD subjects was significantly higher than non-CAD subjects.The multiple Logistic regression analysis showed that hypertension,higher uric acid,hs-CRP,cfPWV and caPWV levels significantly increased the risk of CAD,with ORs （Cl） of 1.47 （1.25-1.74）,1.17 （1.01-1.26）,1.35 （1.10-1.67）,1.15 （1.09-1.19） and 1.07 （1.01-1.15）,respectively.Higher HDL cholesterol was significantly associated with reduced risk of CAD,with ORs （CI） of 0.58 （0.40-0.83）.In addition,cfPWV had significant association with age,hypertension,LDL cholesterol,with Pearson＇s coefficients of 0.166,0.074,and 0.030,respectively.Conclusions cfPWV and caPWV are independently associated with significant CAD,and cfPWV has significant correlation with age and hypertension.cfPWV and caPWV may be used as a practical tool for predicting the risk of CAD.
Zhang Yun Ye Ping Luo Leiming Bai Yongyi Xu Ruyi Xiao Wenkai Liu Dejun Wu Hongmei
To the Editor:Aging is associated with kidney dysfunction and an increased risk of cardiovascular disease.The connection between the cardiovascular system and kidney function is apparent,even in the early stage of renal insufficiency.Cystatin C(CYSC),one of the cystatin superfamily that is expressed in all the nucleated cells,was considered to be one of the best indicators for evaluating renal function.[1]CYSC is a potent inhibitor of cathepsin B(CTSB),which is strictly regulated by CYSC in extracellular matrix remodeling.Imbalances between CYSC and CTSB are connected with atherosclerosis(AS),coronary heart disease,and chronic kidney disease with aging-related phenotypes.Our previous study confirmed that serum CTSB levels were associated with age and decreased cardiovascular-renal functions in healthy adults,[2]suggesting that CTSB exhibits heightened sensitivity to changes in cardiovascular and glomerular function.The present investigation,underlining the role of synthetic and degradative pathways in the aging process,emphasizes that cardio-renal interaction with aging could depend partly on differential expression of some genes leading to an imbalance of functional proteins.In this study,we analyzed the association between renal function,measured by CYSC and estimated glomerular filtration rate(eGFR),and vascular parameters in a healthy Chinese population.
Nan WangXiao-Juan BaiLu-Lu HanWen HanXue-Feng SunXiang-Mei Chen
