Titania nanotubes(TiO2-NTs)are a potential drug vehicle for use in nanomedicine.To this end,a preliminary study of the interaction of a model cell with TiO2-NTs has been carried out.TiO2-NTs were first conjugated with a fl uorescent label,fl uorescein isothiocyanate(FITC).FITC-conjugated titania nanotubes(FITC-TiO2-NTs)internalized in mouse neural stem cells(NSCs,line C17.2)can be directly imaged by confocal microscopy.The confocal imaging showed that FITC-TiO2-NTs readily entered into the cells.After co-incubation with cells for 24 h,FITC-TiO2-NTs localized around the cell nucleus without crossing the karyotheca.More interestingly,the nanotubes passed through the karyotheca entering the cell nucleus after co-incubation for 48 h.Atomic force microscopy(AFM)and transmission electron microscopy(TEM)were also employed in tracking the nanotubes in the cell.These results will be of benefit in future studies of TiO2-NTs for use as a drug vehicle,particularly for DNA-targeting drugs.
Yanli WangJia WangXiaoyong DengJiao WangHaifang WangMinghong WuZheng JiaoYuanfang Liu
In this paper,the TiO_2 nanotubes were synthesized by hydrothermal method using a 10 mol/L NaOH aqueous solution at 150℃. The structure of prepared materials was characterized by X-ray diffraction（XRD）,transmission electron microscopy（TEM）. scanning electron microscope（SEM） and Brunauer-Emmett-Teller（BET）.The prepared TiO_2 nanotubes were used to prepare thick film gas sensors and the gas sensing properties to various gases were tested.Results show the prepared TiO_2 nanotube gas sensors responses to ethanol under dry condition at 450℃.This could be attributed to the fact that it had high porous morphology and a higher pore volume,which can promote the diffusion of ethanol deep inside the films and improve the sensor response. Moreover,the gas sensor made with nanotubes exhibit high selective response towards ethanol gas compared with H_2,CO,acetone.
Yan Li Wang Shun Tan Jia Wang Zhi Jin Tan Qiu Xia Wu Zheng Jiao Ming Hong Wu
