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国家重点基础研究发展计划(21004004)

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发文基金:Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry国家教育部博士点基金国家重点基础研究发展计划更多>>
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An AIEE polyelectrolyte as a light-up fluorescent probe for heparin sensing in full detection range
2013年
Polyelectrolyte PTPEPyH,containing tetraphenylethene(TPE)and pyridinium,was synthesized.Its optical properties were investigated with spectroscopies and the results showed that there were two emission-enhanced stages in the interaction between positive-charged PTPEPyH and negative-charged biomacromolecule heparin.The mechanism was very different due to the reduced non-radiative energy loss and the change of surroundings.The polyelectrolyte PTPEPyH,compared with ChS and HA,also showed high selectivity for heparin in the buffer solution and could be used as a potential bio-probe for heparin quantification in the clinical full range.
CHEN DongYangSHI JianBingWU YanMeiTONG BinZHI JunGeDONG YuPing
关键词:聚电解质肝素生物大分子硫酸软骨素
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