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国家自然科学基金(81172744)

作品数:7 被引量:64H指数:3
相关作者:胡永华李劲吴涛唐迅武轶群更多>>
相关机构:北京大学山西医科大学北京市房山区疾病预防控制中心更多>>
发文基金:国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population被引量:1
2014年
Objective To evaluate the association of known polymorphisms in the lipid metabolic pathway with body mass index (BMI), and estimate their interactions with soybean food intake. Methods A community-based cross-sectional survey was conducted in a Chinese Han population. BMI, soybean food intake, and single nucleotide polymorphisms of rs599839, rs3846662, rs3846663, rs12916, rs174547, rs174570, rs4938303, and rs1558861 were measured in 944 subjects. A multivariate logistic regression was used to analyze the association of the studied polymorphisms with BMIs. The expectation-maximization algorithm was employed to evaluate the extent of linkage disequilibrium between pairwise polymorphisms. The gene-environment interaction was assessed in the general multifactor dimensionality reduction model. Results The polymorphisms of rs3846662 and rs3846663 were associated with 10% highest BMIs when comparing to the 10% lowest values both in individuals and haplotype-based association tests. Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly hisher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64 (95% confidence interval: 1.15-2.34, P〈0.01) after adjusting for the common confounders. Conclusion Our study has sugsested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake.
WANG Jin WeiTANG XunLI NaWU Yi QunLI ShuaiLI JinQIN Xue YingZHANG Zong XinHU Yong HuaCHEN Da Fan
Profile and Correlates of Health-related Quality of Life in Chinese Patients with Coronary Heart Disease被引量:8
2015年
Background: Although coronary heart disease (CHD) is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life (HRQoL) of CHD patients remain unclear. The present study was designed to determine the profile and significant factors of the HRQoL in CHD patients.Methods: A cross-sectional study was conducted in rural communities of Fangshan District, Beijing. China. Socio-demographic, lifestyle, and comorbidity information of CHD patients were collected by a structured questionnaire and medical records. HRQoL was measured using European Quality of Life 5-dimensions (EQ-5D) scale and EQ Visual Analog Scale (EQ-VAS). Multiple linear and logistic regressions were performed to explore the association of potential risk factors with HRQoL scores and each EQ-SD, respectively.Results: Totally, 1928 CHD patients (mean age 61.64 ± 9.24 years; female:male = 2.4:1) were enrolled in the study. The mean score of EQ-5D index and EQ-VAS were 0.889 ±0.172 and 71.56 ±17.65, respectively. Multiple linear regression revealed that marital status, physical activity, moderate alcohol drinking, and family's population were positive independent correlates of EQ-VAS, whereas diabetes mellitus and stroke were negative independent correlates (all P 〈 0.05). Age and stroke were negatively while physical activity, moderate alcohol drinking, family's population and household income were positively correlated with EQ-5D index (all P 〈 0.05) independently. In addition, each of the five HRQoL dimensions had various specific determinants, including obesity, underweight. smoking or education. Conclusions: Findings of the study highlight certain socio-demographic, lifestyle factors, and comorbid stroke or diabetes mellitus as correlates of HRQoL in Chinese CHD patients. Large-scale cohort studies should be carried out to confirm our results in the future.
Ling WangYi-Qun WuXun TangNa LiLiu HeYang CaoDa-Fang ChenYong-Hua Hu
白三烯A4水解酶基因多态性与缺血性脑卒中的关联研究被引量:1
2015年
目的探讨白三烯A4水解酶(u1A4H)基因多态性与缺血性脑卒中(Is)及其亚型的关联性。方法采用表型不一致同胞对研究设计,分析4个LTA4H基因单核苷酸多态性位点(rs2072512、rs2540489、rs2540500和rs6538697)与Is及其亚型的关联关系。采用广义估计方程(GEE)进行多因素分析,采用条件logistic回归模型和以家系为基础的关联检验(FBAT)进行关联分析。结果对234个家系所组成的356对表型不一致同胞对进行分析,发现高血压、糖尿病、高脂血症的患病情况与IS的发病风险存在相关。各位点与Is的关联分析发现,在加性和隐性模型下,rs2540489基因型与IS的关联具有统计学意义,G等位基因是保护因素(加性模型OR=O.62,95%CI:0.41~0.94;隐性模型OR=O.48,95%CI:0.23~1.02);rs2540489基因型与大动脉粥样硬化型(LAA)IS的关联具有统计学意义,G等位基因是保护因素(加性模型OR=0.48,95%C1:0.24—0.95;隐性模型OR=0.25,95%CI:O.07—0.93);在调整年龄、性别等其他因素后,以上关联关系仍然存在。结论LTA4H基因rs2540489位点多态性与大动脉粥样硬化型Is存在关联。
武轶群李帅刘括唐迅方凯李娜李劲吴涛陈大方胡永华
关键词:脑卒中单核苷酸多态性遗传流行病学
FITC-NYZL1分子探针标记膀胱癌患者尿脱落细胞特异性的研究被引量:3
2015年
目的研究FITC-NYZL1分子探针标记尿脱落细胞的特异性,探索其在诊断和监测膀胱癌的临床应用价值。方法收集2014年8月至2015年1月山西医科大学第一医院66例膀胱癌患者尿液,选取12例膀胱炎患者和24名健康人作为对照。固相合成法制备探针FITC-NYZL1,将2h内的新鲜尿液离心、滴片,加入探针孵育,扫描激光共聚焦显微镜(LSCM)观察探针与细胞的结合率,同时取新鲜尿液进行瑞-吉染色。结果 FITC-NYZL1标记膀胱癌患者尿脱落细胞的阳性率为100%(66/66);不同临床分期患者尿脱落细胞的结合率有差异。对照组结合率很低,实验组与对照组间差异有统计学意义(P<0.001)。结论 FITCNYZL1分子探针标记结合膀胱癌细胞,特异性高,可提高膀胱癌患者尿脱落细胞的阳性率;FITC-NYZL1在分期不同的癌细胞中结合率不同,分期越高,荧光探针特异性结合率越高。FITC-NYZL1标记有望成为膀胱癌无创诊断和临床监测的新技术。
罗芳张帆罗俊茜姚红庞建智苏西西杨晓峰
关键词:膀胱癌尿脱落细胞
脑卒中病因流行病学的家系研究被引量:42
2013年
脑卒中是一种由多个遗传和环境因素影响的病因异质性疾病,大量研究表明遗传因素在脑卒中的发生、发展、结局和预后等方面发挥着不容忽视的作用。家系研究通过发现与共享基因和(或)共享环境有关的危险因素来揭示脑卒中等复杂性疾病的潜在病因,是探索遗传和环境相对作用、确定疾病易感基因的最佳策略。近10余年来,不断涌现的各种组学技术、现代分子生物学检测、计算机信息化技术以及高效能统计分析方法为家系资料在遗传流行病学研究中的应用提供了可行性。本文对脑卒中尤其是缺血性脑卒中遗传易感性的家系研究进行综述。
王雪茵胡永华
关键词:脑卒中家系研究遗传流行病学
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