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高等学校学科创新引智计划(B07014)

作品数:58 被引量:126H指数:6
相关作者:胡小唐傅星李艳宁赵会娟鄢志丹更多>>
相关机构:天津大学中国航空工业集团公司中国计量科学研究院更多>>
发文基金:高等学校学科创新引智计划国家自然科学基金天津市自然科学基金更多>>
相关领域:自动化与计算机技术电子电信医药卫生理学更多>>

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58 条 记 录,以下是 1-10
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Tunable microfluidic chip for single-cell deformation study
2023年
Microfluidic phenotyping methods have been of vital importance for cellular characterization,especially for evaluating single cells.In order to study the deformability of a single cell,we devised and tested a tunable microfluidic chip-based method.A pneumatic polymer polydimethylsiloxane(PDMS)membrane was designed and fabricated abutting a single-cell trapping structure,so the cell could be squeezed controllably in a lateral direction.Cell contour changes under increasing pressure were recorded,enabling the deformation degree of different types of single cell to be analyzed and compared using computer vision.This provides a new perspective for studying mechanical properties of cells at the single cell level.
Ruiyun ZhangXuexin DuanShuaihua ZhangWenlan GuoChen SunZiyu Han
关键词:MICROFLUIDICS
基于石英音叉探针的原子力显微镜测头开发被引量:4
2016年
基于石英音叉探针开发了一种自感应原子力显微镜(AFM)测头。该测头通过自身输出电信号检测悬臂振幅变化,无需外部光学检测部件,易于集成。针对测头设计了微弱电流提取及寄生电容补偿电路。利用商业化锁相放大器实现了对测头幅度信号的获取。在此基础上对测头在调幅模式下的力.距离曲线和分辨力进行了测试。利用锁相放大器内置的PID模块实现了调幅模式下对样品表面形貌的测量。实验证明,该测头灵敏度为0.624mV/nm,分辨力优于2nm。
刘雷华郭彤李伟王鹤群高思田
关键词:计量学原子力显微镜锁相放大器
An interdigitated impedance microsensor for detection of moisture content in engine oil
2020年
To address the need for the on-site measurement of aging oil, in this paper, we propose an impedance-based microsensor for analyzing the moisture content in engine oil. Using a microfabrication process, we fabricated an interdigitated microelectrode and integrated it with a 3 D-printed microcontainer to produce a microsensor that can detect changes in the permittivity of oil. When the moisture content in oil increases, this sensor can detect the resulting change in the oil impedance, which is related to its permittivity, and then determine the degree to which the oil has aged. The test results show that the proposed microsensor has the advantages of being small and having high sensitivity, good accuracy, and the ability to be combined with hand-held instruments.The proposed method is expected to be used for the rapid, low cost, on-site determination of oil aging.
Haitao LiuXiecheng TangHao LuWenguang XieYanmin HuQiannan Xue
关键词:MICROSENSOR
Molecular dynamics simulation on the effect of dislocation structures on the retention and distribution of helium ions implanted into silicon
2020年
To investigate the effect of dislocation structures on the initial formation stage of helium bubbles, molecular dynamics(MD) simulations were used in this study. The retention rate and distribution of helium ions with 2 ke V energy implanted into silicon with dislocation structures were studied via MD simulation. Results show that the dislocation structures and their positions in the sample affect the helium ion retention rate. The analysis on the three-dimensional distribution of helium ions show that the implanted helium ions tend to accumulate near the dislocation structures. Raman spectroscopy results show that the silicon substrate surface after helium ion implantation displayed tensile stress as indicated by the blue shift of Raman peaks.
Li JiLei LiuZongwei XuYing SongJintong WuRongrong LiFengzhou Fang
关键词:SILICONDISLOCATION
一种高精度的荧光单分子纳米级定位算法
2010年
荧光成像系统的技术指标、采集的荧光图像信噪比和单分子定位算法是影响单分子定位精度的3大因素.在介绍单分子定位的基本极限精度和理论计算精度的基础上,提出了一种被称为图像去噪高斯掩膜算法的单分子定位算法.依据实验用单分子成像系统的具体配置,通过计算机仿真表明,该算法良好的去噪处理和高斯加权质心运算方式,不仅能实现纳米级的定位精度,而且能突破一般理论计算精度的限制,接近基本极限精度,特别是在背景噪声较大的情况下,其优势更加明显.这对单分子的精确定位和跟踪、扩散方式分析、转移速率计算等具有重要的意义.
鄢志丹孙立东李艳宁胡小唐ZEPPENFELD Peter
计量型AFM力曲线功能的开发及其在纳米振动测量中的应用
2010年
提出了一种在计量型原子力显微镜(AFM)上开发力曲线功能模块的方法.通过在计量型原子力显微镜上增加可调三角波发生器、信号切换和缓冲电压保护电路,对计量型原子力显微镜的内部驱动信号和外加驱动信号进行了平滑切换,避免了原子力显微镜压电陶瓷驱动器的剧烈变化,实现了计量型原子力显微镜的力曲线功能.采用开发的力曲线模块绘制了计量型原子力显微镜的力曲线图形,基于力曲线功能测量了纳米梁谐振器的离面振动特性,并与显微激光多普勒测振仪的测振结果进行了比对,实验结果表明本文提出的方法和建立的系统是正确的.
栗大超邱晗徐临燕傅星胡小唐
关键词:振动测量
Theoretical and experimental characterizations of gigahertz acoustic streaming in microscale fluids被引量:2
2019年
Even as gigahertz(GHz) acoustic streaming has developed into a multi-functional platform technology for biochemical applications, including ultrafast microfluidic mixing, microparticle operations, and cellar or vesicle surgery, its theoretical principles have yet to be established. This is because few studies have been conducted on the use of such high frequency acoustics in microscale fluids. Another difficulty is the lack of velocimetry methods for microscale and nanoscale fluidic streaming. In this work, we focus on the basic aspects of GHz acoustic streaming,including its micro-vortex generation principles, theoretical model, and experimental characterization technologies. We present details of a weak-coupled finite simulation that represents our current understanding of the GHz-acoustic-streaming phenomenon. Both our simulation and experimental results show that the GHzacoustic-induced interfacial body force plays a determinative role in vortex generation. We carefully studied changes in the formation of GHz acoustic streaming at different acoustic powers and flow rates. In particular,we developed a microfluidic-particle-image velocimetry method that enables the quantification of streaming at the microscale and even nanoscale. This work provides a full map of GHz acoustofluidics and highlights the way to further theoretical study of this topic.
Weiwei CuiWei PangYang YangTiechuan LiXuexin Duan
关键词:STREAMINGBODYPIV
一种基于共轭梯度最优化技术的三维时域扩散光学层析方法被引量:3
2009年
扩散光学层析(DOT)中的图像重建是一个面向大参数集的非线性最优化问题,其标准求解方法为牛顿类迭代法,需要对整个Jacobian矩阵进行构建、求逆和存贮,这对大规模的三维问题是不可行的,为此常采用基于逐行线性逆策略的非创伤性填充(ART)技术,图像质量受到严重制约。采用共轭梯度算法,直接求解非线性目标函数梯度,可避免对Jacobian矩阵的操作,为有效降低步长因子求解引起的附加计算量,采用一维不精确搜索算法。通过对双非均匀目标体的平板模型进行模拟成像,与代数重建算法结果进行比较,表明共轭梯度法的重建质量、收敛速度和收敛性都优于ART算法。
杨芳阮平巧高峰赵会娟
关键词:图像处理逆问题共轭梯度算法
基于透射和反射时间分辨测量数据的荧光参数三维重建被引量:6
2009年
提出了一种同时重建荧光参数的全三维时域荧光分子层析方法,通过选择一对合适的拉普拉斯变换因子提取时间扩展曲线的特征信息,求解时域耦合扩散方程。在图像重建过程中,应用代数重建技术求解线性逆问题,且引入归一化玻恩比方法。基于多通道时间相关单光子计数系统对模拟仿体进行了透射和反射式时间分辨数据测量,利用所提方法同时重建了荧光产率和寿命的三维图像。实验结果表明利用反射式测量数据目标体位置、大小、形状等方面具有一定的偏差,透射式达到了较好的重建效果,而两种模式相结合重建效果最优。
张丽敏高峰李娇赵会娟
关键词:生物光学图像重建技术
Design of a hexagonal air-coupled capacitive micromachined ultrasonic transducer for air parametric array被引量:5
2021年
An air parametric array can generate a highly directional beam of audible sound in air,which has a wide range of applications in targeted audio delivery.Capacitive micromachined ultrasonic transducer(CMUTs)have great potential for air-coupled applications,mainly because of their low acoustic impedance.In this study,an air-coupled CMUT array is designed as an air parametric array.A hexagonal array is proposed to improve the directivity of the sound generated.A finite element model of the CMUT is established in COMSOL software to facilitate the choice of appropriate structural parameters of the CMUT cell.The CMUT array is then fabricated by a wafer bonding process with high consistency.The performances of the CMUT are tested to verify the accuracy of the finite element analysis.By optimizing the component parameters of the bias-T circuit used for driving the CMUT,DC and AC voltages can be effectively applied to the top and bottom electrodes of the CMUT to provide efficient ultrasound transmission.Finally,the prepared hexagonal array is successfully used to conduct preliminary experiments on its application as an air parametric array.
Xiaoli ZhangHui ZhangDachao Li
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