Carboxylate as a promising and valuable directing group has attracted a great deal of attention.However,employing it as a traceless direction group has rarely been reported.We developed the ruthenium-catalyzed amidation of substituted benzoic acids with isocyanates via directed C–H functionalization followed by decarboxylation to afford the corresponding metasubstituted N-aryl benzamides,in which the carboxylate serves as a unique,removable directing group.Notably,this protocol can provide an efficient alternative to access meta-substituted N-aryl benzamides,which are much more difficult to prepare than ortho-substituted analogues.
Xian-Ying ShiXue-Fen DongJuan FanKe-Yan LiuJun-Fa WeiChao-Jun Li
