Adsorption of plasma proteins to nanomaterial surfaces has a great influence on their bio-functionality. However, there is limited understanding of the relationship between the functional proteins in the protein corona and the biological identity of the materials. Here we show that the in situ generated thrombin in the protein corona of a Ca-zeolite surface displays a calcium-dependent, unusually high （-3,000 NIH U/mg） procoagulant activity, which is even stable against antithrombin deactivation. Removing the encapsulated Ca^2＋ in the zeolites leads to deactivation by antithrombin. Our observations suggest that the thrombin activity can be regulated by the inorganic surface and cations. Most importantly, our discovery indicates the link between the biomolecules in the protein corona and the procoagulant activity of the materials, providing a new molecular basis for the procoagulant mechanism for zeolite hemostatics.
Yunlong LiXiaofeng LiaoXiaoxi ZhangGuicen MaShuai ZuoLiping XiaoGalen D. StuckyZhugang WangXian ChenXiaoqiang ShangJie Fan
lnkjet printing （IJP） synthesis has emerged as a useful technique for the fabrication of functional metal oxides in the fields of nanotechnology and materials science. In this paper, we will review the fundamental state-of-the-art principles of the special ink formulations used for IJP synthesis of functional metal oxides and the applications of these oxides.
