Microdamage accumulation in bone is one of the mechanisms for energy dissipation during the fracture process. Changes in the ultrastructure and composition of bone constituents due to aging or diseases could affect microdamage accumulation. Low concentration （1 mM） of sodium fluoride （NaF） has been used in this study to investigate the effect of ultrastructural changes on microdamage accumu- lation in mouse tibias following free-fall impact loadings. Twenty-two tibias were divided randomly into control and NaF-treated groups. Free-fall impact loading was conducted twice on each tibia to produce microdamage. The elas- tic modulus of NaF-treated tibias decreased significantly after the impact loadings, while there was no significant difference in the modulus of untreated samples between pre- and post-damage loadings. Microdamage morphology analysis showed that less and shorter microcracks existed in NaF-treated tibias compared with control bones. Meanwhile, more and longer microcracks were observed in tensile regions in untreated samples compared with that in compressive regions, whereas no significant difference was observed between tensile and compressive regions in NaF-treated bones. The results of this study indicate that more energy is required to generate microcracks in NaF-treated bone than in normal bone. A low concentration of fluoride treatment may increase the toughness of bone under impact loading.
为了实现在临床上快速地为病人建立个体化有限元模型用于正畸治疗的术前预测,研究首先在正常颌型志愿者A的CT数据的基础上建立一个包含皮肤、肌肉和脂肪的通用唇面部软组织三维有限元模型。然后通过选取的面部标志点,使用径向基函数(Radial Base Function,RBF)插值法把通用模型变换成志愿者B的唇面部模型而实现通用模型的个体化。结果显示志愿者B的个体化模型和其CT数据在唇面部区域的平均误差在0.47mm左右,而且具有较好的相似度。
