Diatom frustules,considered as novel bio-functional materials,display a diversity of patterns and unique micro-and nanostructures which may be useful in many areas of application.Existing devices directly use the original structure of the biosilica frustules,limiting their function and structural scale.Current research into the shapes,materials and structural properties of frustules are considered;a series of frustule processing methods including structure processing,material modification,bonding and assembly techniques are reviewed and discussed.The aim is to improve the function of diatom frustules allowing them to meet the design requirements of different types of micro devices.In addition,the importance of the comprehensive use of diatom processing methods in device research is discussed using biosensors and solar cells as examples,and the potential of bio-manufacturing technology based on diatom frustules is examined.