国家自然科学基金(30873105)
- 作品数：1 被引量：0H指数：0
- 相关作者：刘皋林汤静更多>>
- 相关机构：上海市第一人民医院更多>>
- 发文基金：上海市自然科学基金国家自然科学基金更多>>
- 相关领域：医药卫生更多>>
- A novel inhibitor of human La protein with anti-HBV activity discovered by structure-based virtual screening and in vitro evaluation
- ＜正＞Background:Over 350 million people worldwide are infected with hepatitis B virus（HBV）,a major cause of live...
- 汤静HUANG Zhi-MinLIU Gao-Lin
- 关键词：DOCKINGINHIBITOR
- 文献传递
- A novel inhibitor of human La protein with anti-HBV activity discovered by structure-based virtual screening and in vitro evaluation
- Background: Over 350 million people worldwide are infected with hepatitis B virus (HBV), a major cause of live...
- TANG JingHUANG Zhi-MinLIU Gao-Lin
- 关键词：DOCKINGINHIBITOR
- 文献传递
- Phosphorylation of human La protein at Ser~(366) by CK2 contributes to HBV replication and expression in vitro
- Human La protein (hLa) is a multifunctional RNA-binding protein involved in the regulation of hepatitis B viru...
- TANG JingHEISE TilmanLIU Gao-Lin
- 关键词：PHOSPHORYLATION
- 文献传递
- A systematic analysis of the predicted human La protein targets identified a hepatitis B virus infection signature
- The human La (hLa) protein functions in RNA metabolism and is activated by casein kinase 2 (CK2) phosphorylati...
- TANG JingLIU Gao-Lin
- 文献传递
- A novel inhibitor of human La protein with antl-HBV activity discovered by structure-based virtual screening and in vitro evaluation
- ＜正＞Aim:The human La（hLa）protein,which forms a stabilizing complex with HBV RNA ribonucleoprotein to promote HB...
- Jing TANGJian ZHANGGao-lin LIU
- 关键词：DOCKINGINHIBITOR
- 文献传递
- A systematic analysis of the predicted human La protein targets identified a hepatitis B virus infection signature
- ＜正＞The human La（hLa） protein functions in RNA metabolism and is activated by casein kinase 2（CK2） phosphorylat...
- 汤静LIU Gao-Lin
- 文献传递
- La蛋白干预HBV RNA代谢的研究进展
- 2009年
- 目的:从La蛋白共价修饰角度,分析La蛋白磷酸化与去磷酸化对其功能的影响,探讨La蛋白与HBV RNA相互作用的分子机制。方法:综述近期人La蛋白的国内外相关文献。结果:人La蛋白是HBV RNA代谢相关蛋白,使HBV RNA免受核酸降解而维持HBV的生命周期,磷酸化是La的激活方式,通过小分子封闭磷酸化位点,可能成为研制抗HBV新药的方向之一。结论:La蛋白可能作为研制抗HBV感染药物的新靶点,拥有更大的研究前景。
- 汤静刘皋林
- 关键词：HBVRNA共价修饰磷酸化
- Phosphorylation of human La protein at Ser366 by CK2 contributes to HBV replication and expression in vitro
- SUMMARY.Human La protein(hLa) is a multifunctional RNA-binding protein involved in the regulation of hepatitis...
- 汤静HEISE TilmanLIU Gao-Lin
- 关键词：PHOSPHORYLATION
- 文献传递
- 基于虚拟筛选技术发现的具有抗乙肝病毒作用的靶向人La蛋白新型抑制剂及其体外生物活性验证(英文)
- 背景:全球超过3.5亿人感染乙肝病毒(HBV),导致肝衰竭和肝癌。目前的治疗药物虽然能在一定程度控制感染,但由于耐药率的不断上升,治疗效果越来越差强人意。因此,急需找到具有靶向特异性的新型药物。人La蛋白能与HBV RN...
- 汤静黄志敏陈颖毅张健刘皋林
- 关键词：乙型肝炎病毒抑制剂
- 文献传递
