Over the last 20 years,intensive research has been focused on the specific mechanisms mediating the pancreatic β-cell injury.Both the decreased viability and the dysfunction of β-cells have become the key factors in the development of dia betes mellitus.Thus,it is of utmost importance to elucidate the discrete pathological changes in pancreatic β-cells within the context of the various lipotoxicity models.The goal of these studies is to generate evidence to improve not only the clinical treatment for dia betics,but also modulate the diet and activities of groups at high risk for diabetes.In this regard,we review the role of lipotoxicity in pancreatic β-cell injury and identify potential therapeutic targets in this cell model.
Objective Interactions of tumor cells with endothelial cells(ECs),for example tumor cell adhesion and migratio...
Yan PAN,Xuejun LI (State Key Laboratory of Natural and Biomimetic Drugs,Department of Pharmacology, School of Basic Medical Sciences,Peking University and Institute of System Biomedicine, Peking University,Beijing 100191,China )
