The simulation techniques of hardware-in-loop simulation(HLS) of homing antitank missile based on the personal computer (PC) are discussed. The PC and MCS-96 chip controller employ A/D and D/A boards (with photoelectricity isolation) to transfer measur ment and control information about homing head, gyro and rudder and utilize the digital hand shaking board to build correct communication communication protocol. In order to satisfy the real-time requirement of HLS, this paper first simplifies the aerodynamic data file reasonably, then builds a PC software with C language. The program of the controller part is made with PL/M language. The simulation of HLS based on PC is done with the same sampling period of 10ms as that of YH-F1 and the experiment results are identical to those of digital simulation of the homing anti-tank guided missile.