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许晓康

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44 条 记 录,以下是 1-10
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电针对血管性痴呆大鼠海马谷氨酸、钙离子含量及N-甲基-D-天冬氨酸受体表达的影响被引量:26
2016年
目的:观察电针对血管性痴呆(VD)大鼠海马组织谷氨酸(Glu)、钙离子(Ca^(2+))含量和N-甲基-D-天冬氨酸受体(NMDAR)表达及其学习记忆能力的影响,探讨电针治疗VD的作用机制。方法:SD大鼠随机分为假手术组、模型组和电针组。采用反复阻断双侧颈总动脉加腹腔注射硝普钠的方法制备缺血再灌注VD模型大鼠。电针组电针"大椎""百会"和双侧"后三里""膈俞",每次10min,每日1次,连续15d。观察各组大鼠跳台学习记忆成绩,分光光度计法检测海马组织Glu及Ca^(2+)含量,免疫蛋白印迹法检测NMDAR表达。结果:与假手术组比较,模型组大鼠卒中指数及神经功能评分显著升高(P<0.05),学习和记忆成绩均显著降低(P<0.01),海马组织Glu、Ca^(2+)含量及NMDAR表达均显著增高(P<0.01)。与模型组比较,电针组大鼠学习记忆成绩显著提高(P<0.01),Glu、Ca^(2+)含量及NMDAR表达明显降低(P<0.01)。结论:电针可明显改善VD大鼠的学习记忆能力,其作用机制可能与其抑制Glu-NMDAR的神经兴奋毒性,减轻细胞内Ca^(2+)负荷,对抗神经细胞损伤有关。
张茜张闯张佳音张会珍李晓峰肖红玲孙彦辉邢海娇许晓康梁玉磊张莘张晓琪李爱英
关键词:血管性痴呆海马学习记忆能力谷氨酸
Revitalization and application of ancient round-sharp needle based on Nèijīng被引量:4
2016年
The emergence of nine needles in Nèijīng(《内经》, The Inner Classic) laid a foundation for the formation and development of needling instruments and acupuncture manipulation in later ages, but the application of nine needles was not realized during clinical practice of acupuncture-moxibustion in later ages. Round-sharp needle is one of the nine needles. In this study, round-sharp needle was taken as an example to introduce the excavation and revitalization of nine needles and diagnosis and treatment rules explored by Mr. CHEN Lixin according to The Inner Classic. The needle shape, needling manipulation and clinical application of round-sharp needle based on The Inner Classic were described in detail.
梁玉磊张霞孙彦辉许晓康李晓峰
关键词:REVITALIZATION
近十年针灸治疗单纯性肥胖症的成效与展望被引量:2
2016年
随着人们物质生活水平的不断提高,肥胖症的发病率迅速增长,严重威胁着人类的健康。目前,应用针灸治疗单纯性肥胖症的临床研究报道颇多,疗效确切。现将近10年来针灸治疗单纯性肥胖症的临床进展进行综述,并对其治疗研究中所存在的问题提出一些看法和展望。
高飞许晓康梁玉磊孙小雪杜潇怡孙立虹
关键词:针灸治疗单纯性肥胖症体针穴位埋线耳针灸法
不同频率电针治疗血管性痴呆的实验研究进展被引量:3
2016年
目的:血管性痴呆(VD)是脑血管病的常见并发症之一,在严重影响患者生活质量的同时也给社会和家庭带来沉重负担。电针治疗血管性痴呆的优势突出,但所选择的频率不尽相同。本文通过对2000年以来不同频率电针治疗VD的实验研究结果总结发现,不同频率电针治疗本病均获得良好效果。
贾睿帼张茜张佳音张闯梁玉磊许晓康张会珍
关键词:血管性痴呆电针低频电针高频电针
不同频率电针对血管性痴呆小鼠海马组织自由基的影响
目的 探讨2 Hz、80 Hz和2/80 Hz 3种不同频率电针对血管性痴呆模型小鼠海马组织自由基的差异性.方法 将100只昆明小鼠随机分为假手术组、模型组、2 Hz组、80 Hz组、2/80 Hz组,每组20只.以反复...
武泽惠许晓康梁玉磊张闯张晓琪张莘张选平张会珍郭菲
关键词:电针海马自由基
基于数据挖掘的穴位贴敷疗法运用特点研究被引量:106
2012年
目的:探讨穴位贴敷疗法效应特异性规律与特点,以更好地指导临床决策。方法:采用现代计算机与数据挖掘技术,建立穴位贴敷数据库,对近60年来穴位贴敷相关文献进行收集、整理、筛选、录入、审核、提取数据、统计分析,总结穴位贴敷在临床治疗的优势病种和应用规律。结果:从数据挖掘结果可以看出,穴位贴敷疗法在临床各科疾病均有使用。其中以内科疾病最多,涉及病种占疾病种类总数的35.92%(51/142),并以哮喘、咳嗽、腹痛为多;其次为儿科,涉及病种占病种总数的21.13%(30/142),并以小儿咳嗽、小儿哮喘、小儿泄泻为多;外科涉及病种占总数的19.01%(27/142),并以腰腿痛为最多;五官科涉及病种占总数的9.86%(14/142),并以鼻渊最多;妇科涉及病种占总数的7.04%(10/142),以经行腹痛为最多;皮肤科涉及病种占总数的7.04%(10/142),有蛇串疮等。贴敷用药多选用复方中药剂;药物制作以膏剂和糊剂为主;助渗剂使用较少;选穴以近部选穴为主;在临床各科疗效中以皮肤科痊愈率最高,其次为外科、妇科、儿科、内科、五官科,各科总有效率均在90%以上。结论:穴位贴敷疗法应用于临床各科的142种疾病。优势病种为内科的哮喘、咳嗽、腹痛、面瘫、便秘;儿科的小儿咳嗽、小儿哮喘、小儿泄泻;外科的腰腿痛;五官科的鼻渊;妇科的经行腹痛。
张莘张选平贾春生王建岭徐晶覃亮许晓康张美玲康素刚段晓东刘蓓蓓蔡春莹
关键词:数据挖掘临床病症
Study on the effect of moxibustion at “Shénquè”(神阙 CV 8) on the immune system of rats taking long-term exhaustive exercise被引量:5
2017年
Objective To explore the effect of moxibustion at "Shénquè"(神阙 CV 8) on the immune system of rats taking long-term exhaustive exercise.Method Thirty male SD rats were randomly divided into blank group,model group and moxibustion group with 10 rats in each group.Except the rats in blank group,all the rats were established into long-term exhaustive models through swimming again and again.Mild moxibustion at CV 8 for 15 min was carried out in the rats in moxibustion group after modeling.The treatment was conducted once every other day,and treatment for 10 times was needed.The exhaustive duration for each time was recorded,the levels of serum Ig A,Ig G,Ig M and ACP were detected 24 h after the 10 th exhaustive exercise,and the histomorphological changes of spleen were observed.Immunoturbidimetry was adopted for detecting the Ig A level,and ELISA method was used for detecting the levels of Ig G,Ig M and ACP.Results The common exhaustive duration in moxibustion group was longer than that in model group,however,the time difference was statistically significant after the 5th exhaustive exercise(P0.01).The levels of serum IgG and IgM in model group were lower than that in blank group(all P0.01),and the serum ACP level in model group was higher than that in blank group(P0.01),indicating that the splenic histomorphology was damaged.The levels of serum Ig G and Ig M in moxibustion group were higher than that in model group(all P0.01),and the serum ACP level in moxibustion group was lower than that in model group,showing that the splenic histomorphology was repaired.Conclusion Moxibustion at CV 8 can improve the levels of immunoglobulin(Ig G,Ig A,Ig M) of tired body for a long time,decrease the ACP level,and repair the damaged spleen tissues.
梁玉磊许晓康周小红高飞孙立虹祝婕张闯丁晨光李晓峰李新华
关键词:IMMUNOGLOBULINACP
基于数据挖掘技术的穴位注射疗法效应特点研究及穴位注射治疗呃逆的系统评价
目的:穴位注射疗法作为刺法灸法学的重要部分,自20世纪50年代应用于临床以来,获得了良好的临床疗效。本研究以穴位注射疗法的特异性规律和特点为出发点,收集论文、医籍及医案记载,挖掘、发现穴位注射疗法在临床适宜疾病的科属和种...
许晓康
关键词:呃逆穴位注射疗法数据挖掘
Exploration to the disease spectrum of acupoint catgut-embedding therapy被引量:4
2012年
Objective To explore the clinically indicated diseases of acupoint catgut-embedding therapy, and summarize and analyze the disease spectrum of acupoint catgut-embedding therapy. Methods By literature research and data mining technique, the clinical study papers relevant to acupoint catgut-embedding therapy published from 1971 to June 2011 were selected, entered and verified, then the effective information were extracted, and finally, the disease spectrum were summarized. Results Acupoint catgut-embedding therapy is indicated for 103 diseases, involving 6 departments, of which there are 50 internal diseases, which is the most, accounting to 48.54%, and 15 surgical diseases, 12 ENT diseases, 11 gynecological diseases and 11 dermatological diseases, and 4 pediatric diseases, which is the least. Meanwhile, according to the rule of "Efficacy acupuncture grading disease spectrum", the diseases treated with this therapy were graded preliminarily into grade Ⅰ with 26 diseases, grade Ⅱ with 30 diseases, and grade Ⅲ with 8 diseases. Conclusion Acupoint catgut-embedding therapy can be used widely in clinical treatment with much broader disease spectrum, and it is worthy of being spread and applied.
康素刚张美玲段晓东张选平张莘许晓康贾春生王建岭
针刺对不同性别单纯性肥胖大鼠Lee's指数与Leptin含量的影响被引量:9
2015年
目的:比较针刺干预对不同性别单纯性肥胖大鼠Lee’s指数和血、脑瘦素(Leptin)含量的影响,探讨针刺塑形效果与性别的差异性及可能作用机制。方法:采用谷氨酸钠和高脂饮食诱导法制造下丘脑性肥胖大鼠模型,随机分为模型雌组、雄组,治疗雌组、雄组,另设正常雌组、雄组,每组8只大鼠。治疗组毫针刺曲池、中脘、关元、后三里、丰隆、三阴交穴,每日1次,连续治疗28 d。观察治疗前后雌、雄两组大鼠Lee’s指数和血清、下丘脑Leptin含量的变化,并进行统计比较。结果:与模型雌组、雄组比较,治疗雌组、雄组的Lee’s指数和血清、下丘脑Leptin的含量均明显改善(P<0.01),且治疗雄组优于治疗雌组(P<0.05)。结论:针刺对雌雄两性单纯性肥胖大鼠均可起到减肥作用,但在减肥塑形方面,对雄性的疗效优于雌性。
董乃相张书义梁玉磊许晓康肖红玲孙永辉孙立虹
关键词:针刺单纯性肥胖
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