This review focused on the diagnosis and clinical features of multiple sclerosis(MS) in China. We have identified the published researching information from 1976 to 2008 in China. The key issues related to the diagnosis and clinical features of MS in China were summarized. The first patient with MS in China was reported in 1926 from Xiehe hospital. Case reports on MS has been increasing during recent decades. Almost all the patients with MS were confirmed by the McDonald criteria(1977) before1984. After the...