Objective: To investigate the coping ways of enterprise managers and their effect on mental health. Methods: 136 enterprise managers were surveyed by using WCRS (edited by Baoyong Liang) and SCL-90. Results:In accordance with the Six Factors of Coping Ways Model (by Baoyong Liang), the scores of catharsis and acceptance factor of the managers were relatively higher than those of others and their score of partial attribution factor were the lowest. The enterprise managers usually adopted two coping ways, which was significantly related to the results examined by SCL-90. Conclusion: Different coping ways of enterprise managers have a significant effect on their mental health.