目的探讨高功率密度低频超声辐照模式对超声促进药物释放的影响。方法制备质量分数10％的载万古霉素骨水泥（vancomycin-loaded bone cenlent，VLBC）圆柱体试件。随机分为对照组、超声连续辐照组、超声间断辐照组，后两组接受超声辐照14d。浸泡28d内定时测定万古霉素浓度，计算有效抑菌浓度维持时间（T〉MIC）、14～28d亚抑菌浓度释药量、14d内累积释药量并行曲线拟合；浸泡14d后行扫描电镜观察。结果超声间断辐照组T〉MIC。较列照组及超声连续辐照组分别提高6．56d、7．09d，超声连续辐照组较对照组下降0．53d。超声间断辐照组亚抑菌浓度释药量较对照组及超声连续辐照组分别下降0．16mg、0．19mg；14d累积释药量较对照组及超声连续辐照组分别提高2．88mg、2．81mg。三组采用指数增长至最大值模型拟合效果均理想，超声间断辐照组M0、Mmax-M0、K均较对照组及超声连续辐照组提高，超声连续辐照组M0较对照组提高，但Mmax-M0、K、N较对照组降低。结论高功率密度低频超声间断辐照对VLBC的表面释放和内部弥散有明显的促进作用，连续辐照抑制VLBC的内部弥散。
Objective To further reveal serious risks of heroin abuse to human body and clarify grave injuries of oxidation, peroxidation and lipoperoxidation induced by nitric oxide and other free radicals to heroin abusers Methods Determined and compared plasma levels of nitric oxide (P NO), vitamin C (P VC), vitamin E (P VE), β carotene (P β CAR), lipoperoxides (P LPO) and erythrocyte activities of superoxide dismutase (E SOD), catalase (E CAT), glutathione peroxidase (E GSH Px) and erythrocyte level of lipoperoxides (E LPO) in 137 cases of heroin abusers (HAs) and 100 cases of healthy volunteers (HVs), used linear regression and correlation, stepwise regression and correlation to analyze correlation among heroin abusing duration (HAD), daily heroin abusing quantity (DHAQ) with above determination values in the HAs Results Compared with the above average values in the HVs group, the average values of P NO, P LPO, E LPO in the HAs group were significantly increased ( P <0 0001), the average values of P VC, P VE, P β CAR, E SOD, E CAT and E GSH Px were significantly decreased ( P <0 0001); the analysis of linear regression and correlation showed that with ascending of the HAD and DHAQ in the HAs, the values of P NO, P LPO, E LPO were gradually increased ( P <0 0001), the values of P VC, P VE, P β CAR, E SOD, E CAT, E GSH Px were gradually decreased ( P <0 0001); the analysis of stepwise regression and correlation suggested that the correlation among the HAD, DHAQ with the values of P NO, P VC, P VE was the closest Conclusion The balance between oxidation and antioxidation in the HAs was seriously destroyed, and the injuries induced by nitric oxide and other free radicals, oxidation, peroxidation and lipoperoxidation reactions to the body of HAs gravely exacerbated In the abstaining from heroin dependence, therefore, it should consider that sufficient quantum antioxidants such as VC, VE and β CAR are dosed to the HAs so as to ab
