目的比较帕金森病(Parkinson disease,PD)患者和健康对照者多个脑结构的相位偏移值,探讨其诊断PD的价值。方法30例PD患者及30名年龄相匹配的健康对照者均在1.5 T MR系统中进行头部检查。采用磁敏感成像(susceptibility-weighted imaging,SWI)获得相位图,测量双侧尾状核、壳核、黑质致密带(substantianigra pars compacta,SNc)、黑质网状带(substantia nigra pars reticulata,SNr)、红核、脑脊液(cerebrospinal fluid,CSF)、额叶白质(frontal grey matter,FWM)及额叶皮质(frontal white matter,FGM)感兴趣区的相位偏移值。结果PD组SNc、尾状核、红核的相位偏移值均数较健康对照组明显降低(P<0.05),两组间SNr、壳核、CSF、FWM、FGM的相位偏移值差异无统计学意义(P>0.05)。结论通过测定PD患者脑感兴趣区相位偏移值可估测其脑内铁沉积。
Objective To compare the phase radians in several cerebral regions between patients with Parkinson’s disease (PD) and control subjects, and to evaluate whether iron deposition quantified by susceptibility-weighted imaging (SWI) is related to the severity of motor symptoms of PD. Methods SWI consisted of both magnitude and phase images from a fully flow-compensated, 3-dimensional and gradient-echo (GRE) sequence. Magnitude and phase data were collected at GE HD 1.5T. The regions evaluated included frontal white matter, grey matter, cerebrospinal fluid, putamen, caudate nucleus (CN), sub- stantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr), and red nucleus (RN). A total number of 42 patients (12 patients without cognitive dysfunction, and 30 with cognitive dysfunction from mild to moderate degrees) and 30 control subjects were employed in the present study. Results The phase radians of SNc, CN and RN in PD patients were lower than those in control subjects (P〈0.05). Conclusion The phase radians can be used to estimate the brain iron deposition in PD patients, which may be helpful in the diagnosis and longitudinal monitoring of PD.