2009年度诺贝尔化学奖授予了美国科学家Venkatraman Ramakrishnan、Thomas A. Steitz和以色列科学家Ada E. Yonath,以表彰他们"对核糖体结构和功能的研究"。高分辨率的核糖体晶体结构使得人们能够在原子水平深入精确地理解核糖体的分子机制,并且为基于结构的合理化抗生素设计打下了坚实基础。以色列女科学家Ada E. Yonath是整个核糖体晶体结构研究领域的核心人物,她10多年坚持不懈地进行多种细菌核糖体的提纯与晶体生长工作,才使得核糖体高分辨率晶体结构解析成为可能。本文对2009年度诺贝尔化学奖的研究工作进行简要介绍。
2017年2月6日,Nature Methods杂志在线发表了加拿大多伦多大学和约克大学的电子工程与计算机科学系、生物化学系、医学生物物理系等多学科人员联合组成的研究小组开发的应用于冷冻电子显微镜（cryo-electron microscopy,cryo-EM）生物大分子结构解析的软件,cryoSPARC（cryo-EM single-particle ab initio reconstruction and classification）,可以进行由低到高分辨率的快速、自动化的生物大分子结构解析.
Ti-based biomaterial has been widely used as dental and bone implant material although its bioacti-vity still needs improvement especially for dental implant.The bone morphogenetic proteins(BMPs) bound to Ti-based materials will attract the mesenchymal stem cells to differentiate into osteoblast cells,which benefits the response to the protein-material surface,and finally leads to new bone formation.Several methods including physically mixing,coating,plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials.The latest research papers are focused on the structure and function of BMPs,and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.
