目的观察尤瑞克林治疗急性颈内动脉系统脑梗死患者的临床疗效及其对惠侧脑循环动力学的影响。方法急性单侧颈内动脉系统脑梗死患者78例,随机分为尤瑞克林治疗组和对照组。两组均给予抗血小板药物等常规治疗,治疗组另加用尤瑞克林治疗,疗程14d。在治疗前、后分别用美国国立卫生研究所脑卒中评分(National Institutes of Health Stroke Scale,NIHSS)评估两组患者的神经功能缺损程度,检测两组患者的脑循环动力学指标(cerebralvasculardynamics indexes,CVDI),比较两组之间及治疗前后神经功能及脑循环动力学变化。结果急性脑梗死患者经尤瑞克林治疗后神经功能恢复明显优于对照组,NIHSS评分、临床总有效率均显著改善(P<0.05)。两组患者治疗后惠侧颈动脉最小血流速度、平均血流速度、最小血流量及平均血流量均较治疗前明显增加(P<0.05,P<0.01),外周阻力均有所下降(P<0.01);治疗组治疗后最小血流速度、平均血流速度、最小血流量及平均血流量的增加及外周阻力的下降均较对照组更明显(P<0.01)。治疗组治疗后的血管特性阻抗显著降低(P<0.01)。结论尤瑞克林能改善急性脑梗死患者脑循环动力学指标,降低脑血管的阻力,增加脑动脉的供血量,促进神经功能恢复。
Objective To investigate the status of vitamin B 12 deficiency in elderly inpatients in the department of neurology. Methods A total number of 827 patients in the department of neurology of Shanghai Punan hospital, from March 2007 to July 2008, were employed in the present study. They were 60 years or older, and the average age was 77.1±7.5 years old. All the patients were diagnosed with no severe hepatic or renal dysfunction, without any usage of vitamin B 12 during the previous 3 months before the detection. The levels of serum vitamin B 12, folate and homocysteine （Hcy） were evaluated. The patients with vitamin B 12 deficiency were screened. The resulting symptoms, positive signs of neurological examination, and the neuroelectricphysiological results were compared between patients with or without vitamin B 12 deficiency. Results Vitamin B 12 deficiency was found in 163 patients （19.71% of the total patients）, and was more prevalent in female than in male patients, also with increased incidences with aging. Patients with low levels of serum vitamin B 12 exhibited higher rate of gastrointestinal diseases, while only 9.82% of the vitamin B 12 deficient patients had megaloblastic anemia. Symptoms of vitamin B 12 deficiency included unsteadily walking in the darkness and hypopallesthesia, and some chronic diseases such as cerebral ischemia, hypertension, Parkinson＇s disease （Parkinsonism）, diabetes mellitus and coronary heart disease. Most of the vitamin B 12 deficient patients had neuroelectricphysiological abnormalities. Conclusion Vitamin B 12 deficiency is remarkably common in elderly patients in neurology department, with various and atypical clinical manifestations, and the neurological symptoms are more common than megaloblastic anemia symptoms.
