The development of unconventional resources, such as shale gas and tight sane gas, requires the integration of multi-disciplinary knowledge to resolve many engineering problems in order to achieve economic production levels. The reservoir heterogeneit3 revealed by different data sets, such as 3D seismic and microseismic data, can more full3 reflect the reservoir properties and is helpful to optimize the drilling and completioT programs. First, we predict the local stress direction and open or close status of the natura fractures in tight sand reservoirs based on seismic curvature, an attribute that reveals reservoi heterogeneity and geomechanical properties. Meanwhile, the reservoir fracture network is predicted using an ant-tracking cube and the potential fracture barriers which can affec hydraulic fracture propagation are predicted by integrating the seismic curvature attribute anc ant-tracking cube. Second, we use this information, derived from 3D seismic data, to assis in designing the fracture program and adjusting stimulation parameters. Finally, we interpre the reason why sand plugs will occur during the stimulation process by the integration of 3E seismic interpretation and microseismic imaging results, which further explain the hydraulic fracure propagation controlling factors and open or closed state of natural fractures in tigh sand reservoirs.