搜索到12665篇“ AFFINITY“的相关文章
基于固定化金属亲和整体柱的痕量微囊藻毒素富集分析
2025年
基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体柱的萃取条件,在最优条件下,将poly(VIM-co-DVB)-Cu^(2+)整体柱用于毛细管微萃取(CME),并与高效液相色谱-质谱(HPLC-MS)检测技术联用,建立了环境水样品中3种MCs的高效富集分析方法。方法检出限为0.89~1.23 ng/L,加标回收率为80.0%~105%,相对标准偏差(RSD)不大于6.8%。该方法灵敏度高、准确性好,可为污染水体中微囊藻毒素的监测分析提供有效手段。
陈小燕杨玲苏立燊吴晓苹
关键词:微囊藻毒素高效液相色谱-质谱
多体非完全经典态的基于Affinity的关联测度
2024年
在量子信息理论中,量子关联是一种极其重要的物理资源。文章首先定义了多体非完全经典态基于Affinity的一种量子关联测度,它可以量化多体非完全经典态的关联程度;接下来证明了该关联测度满足量子关联度的一些必要物理性质,包括非负性、局部酉操作下的不变性、局部量子操作下的单调性、凸性以及连续性。
闫栋华王银珠
关键词:AFFINITY
冶金与地球化学过程中Fe-Co-Ni-Cu亲氧性和亲硫性规律
2024年
Fe、Co、Ni、Cu在冶金上的提取分离与地球化学成矿在原理上具有高度的相似性,例如岩浆熔离成矿与火法冶金、热液成矿与湿法冶金、风化成矿与湿法冶金、生物地球化学成矿与生物冶金。元素在地球化学迁移和冶金提取过程中体现出的化学性质相似,在地球化学过程中,Fe、Co、Ni、Cu经常伴生成矿,如铁镍矿、镍钴矿、铜钴矿等硫化或氧化类矿物;在冶金过程中,这四个元素则体现出很强的亲氧亲硫化学规律性。利用过渡金属元素Fe、Co、Ni、Cu在成矿中显现出的元素亲和性差异作为相似元素相互分离的理论指导,可以从新的角度理解提取冶金。本文通过分析四种元素的地球化学行为与冶金行为,发现其对氧的亲和性顺序为Fe>Co>Ni>Cu,对硫的亲和性顺序为Fe
王帅孙丰龙赵中伟
关键词:提取冶金地球化学
Strategies for Enhancing the Affinity of College Ideological and Political Course Teachers
2024年
This article aims to explore effective ways to enhance the affinity of ideological and political course teachers in universities.By analyzing the connotation of affinity,the factors that affect the affinity of ideological and political course teachers are analyzed,and corresponding improvement strategies are proposed.Research suggests that strengthening the construction of teacher ethics and conduct,improving teaching skills,enhancing emotional engagement,and enhancing practical training are key paths to enhance the affinity of ideological and political course teachers.The implementation of these paths will help improve the teaching quality and effectiveness of ideological and political courses,and promote the comprehensive development of students.
WANG Na
多示例嵌入学习的实例关联性挖掘与强化
2024年
提出了多示例嵌入学习(multi-instance learning,MIL)的实例关联性挖掘与强化算法(multi-instance embedding learning with instance affinity mining and reinforcement,MEMR),包括3个技术。关联性挖掘技术基于自定义的关联性指标,首先在负实例空间中选择初始负代表实例集,然后根据正、负实例间的差异性,选择初始正代表实例集。关联性强化技术分别评估初始正、负代表实例集与整个实例空间的正负关联性,获得整体关联性更强的代表实例集。包嵌入技术通过嵌入函数将包转换为单向量进行学习。实验在4类应用领域和7种对比算法上进行。结果表明,MEMR的准确性总体优于其他对比算法,特别是在图像检索和网页推荐数据集上具有显著优势。
杨梅邓雯杨梅闵帆
关键词:嵌入方法多示例学习
15份白菜型油菜两种授粉方式的亲和性比较
2024年
油菜是重要的油料作物,其授粉方式对自交亲和性的影响较大。该试验通过对参试材料采用自由授粉、套袋自交两种授粉方式,并分析黄籽油菜与非黄籽油菜的自交亲和性。结果发现,黄籽油菜的平均结角率均低于非黄籽油菜。而对于每果粒数而言,除原油706056、黄油1号、贡麦黄籽外,其余黄籽油菜的套袋自交每果粒数为7.66粒、自由授粉的每果粒数为10.10粒;非黄籽油菜的套袋自交的每果粒数为2.83粒、自由授粉的每果粒数为13.88粒,参试黄籽油菜材料的自交亲和指数普遍高于非黄籽材料,且黄籽油菜与非黄籽油菜之间自交亲和指数相差为4.2。该研究对于白菜型油菜的改良和选育具有重要意义。
陈杨杨晓海江伦娟格桑曲珍旦巴
关键词:白菜型油菜黄籽油菜授粉方式自交亲和性
Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy
2024年
Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic mechanism.The Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat psoriasis.Although previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain unexplored.This study aimed to unveil the anti-psoriasis molecular targets and active components of OYF.Our findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 cells.We synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target Fishing.The enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene network.We identified a total of 76 potential target proteins,which were highly associated with mRNA transcription mechanisms.In particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF extract.We further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23 expression.Additionally,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse model.Collectively,our study elucidates the primary molecular targets and active components of OYF,offering novel insights for psoriasis treatment.
WANG WeiLIU LijuanYANG ZhuoLU ChuanjianTU PengfeiZHAO RuizhiZENG Kewu
关键词:PSORIASIS
A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries被引量:2
2024年
Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety.
Guowei YuGuofeng YeCheng WangChenyang WangZhaoyun WangPu HuYu LiXi-Xi FengShuang-Jie TanMin YanSen XinZhitian Liu
Self-optimized H-adsorption affinity of CuRu alloy cocatalysts towards efficient photocatalytic H_(2)evolution被引量:1
2024年
In addition to the electron transfer,the appropriate H-adsorption affinity of active centers on the metal cocatalyst surface is quite important for high hydrogen-production activity of cocatalyst-modified photo-catalysts.The typical Cu and Ru metal cocatalysts clearly exhibit a weak Cu-H bond and a strong Ru-H bond,respectively,resulting in limited activity for photocatalytic H_(2)evolution.In this work,an ingenious strategy of self-optimized H-adsorption affinity in CuRu alloy cocatalyst is developed to simultaneously reinforce the Cu-H bond and weaken the Ru-H bond by the intrinsic electron transfer from Cu to Ru atom.The CuRu alloy nanoparticles(2-3 nm)were deposited on the TiO_(2)surface to prepare CuRu/TiO_(2)through a one-step photoreduction method.Photocatalytic tests exhibited that the highest H_(2)-production rate of CuRu/TiO_(2)photocatalyst reached up to 5.316 mmol h^(-1)g^(-1),which was 24.80,1.86,and 2.60 times higher than that of the TiO_(2),Cu/TiO_(2),and Ru/TiO_(2),respectively.Based on the characterization results and theoretical calculations,the CuRu alloy cocatalyst exhibits excellent self-optimized H-adsorption affinity via the spontaneous electron transfer from Cu to Ru atom,which can greatly accelerate the photocatalytic H_(2)-production rate of TiO_(2).This work provides a feasible idea for the self-optimized H-adsorption affinity of metal active sites in the photocatalytic H_(2)-generation field.
Meiya WangPing WangXuefei WangFeng ChenHuogen Yu
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion
2024年
Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles.Point mutations,particularly those within the receptor binding domain(RBD)of SARS-CoV-2 spike(S)protein,lead to the functional alteration in both receptor engagement and monoclonal antibody(mAb)recognition.Here,we review the data of the RBD point mutations possessed by major SARS-CoV-2 variants and discuss their individual effects on ACE2 affinity and immune evasion.Many single amino acid substitutions within RBD epitopes crucial for the antibody evasion capacity may conversely weaken ACE2 binding affinity.However,this weakened effect could be largely compensated by specific epistatic mutations,such as N501Y,thus maintaining the overall ACE2 affinity for the spike protein of all major variants.The predominant direction of SARS-CoV-2 evolution lies neither in promoting ACE2 affinity nor evading mAb neutralization but in maintaining a delicate balance between these two dimensions.Together,this review interprets how RBD mutations efficiently resist antibody neutralization and meanwhile how the affinity between ACE2 and spike protein is maintained,emphasizing the significance of comprehensive assessment of spike mutations.
Song XueYuru HanFan WuQiao Wang
关键词:ACE2AFFINITY

相关作者

王银珠
作品数:41被引量:12H指数:2
供职机构:太原科技大学应用科学学院
研究主题:量子态 整体解 GALERKIN方法 无限维 可分性
王开军
作品数:39被引量:99H指数:6
供职机构:福建师范大学
研究主题:粒子滤波 状态空间模型 贴近度 粒子滤波算法 故障预测
张荣华
作品数:52被引量:148H指数:7
供职机构:云南省第二人民医院
研究主题:急性心肌梗死 心脏起搏 心房颤动 尿激酶 心血管病学
赵怡然
作品数:3被引量:0H指数:0
供职机构:北京大学
研究主题:白细胞粘附 血管内皮细胞 毛细管 细胞 拮抗
李健
作品数:1被引量:1H指数:1
供职机构:西北政法大学
研究主题:CLUSTERING AFFINITY PROPAGATION