搜索到8529篇“ PROCALCITONIN“的相关文章
降钙素原被引量:82
2008年
综述降钙素原(PCT)的产生、代谢特点、临床应用价值及PCT对鉴别细菌或病毒性感染、判断感染严重程度和预后的重要意义。
吴熙于学忠
关键词:降钙素原自身免疫性疾病器官移植脓毒症急性胰腺炎
使用降钙素原轨迹识别脓毒症亚表型及风险分层研究
2025年
背景脓毒症是一种异质性疾病,识别脓毒症亚表型有助于优化脓毒症管理。目的利用降钙素原(PCT)轨迹识别脓毒症亚表型并进行风险分层。方法回顾性分析2021-01-01至2023-08-01宁夏医科大学总医院收住的800例及甘肃省人民医院收住的202例成年脓毒症患者(年龄>18岁),随机将宁夏医科大学总医院其中597例患者纳入开发队列(60%),另外203例及甘肃省人民医院202例共405例患者纳入验证队列(40%)。首先根据患者28 d生存情况,将开发队列分为存活组与死亡组,分析不同时间PCT测量值(PCT第1天、第3天、第5天、第7天分别标记为PCT d1、PCT d3、PCT d5、PCT d7)对脓毒症的预后价值,并绘制受试者工作特征(ROC)曲线评估预测效能;然后,基于PCT重复测量进行组基轨迹建模以识别脓毒症亚表型,根据PCT变化趋势及临床特征对亚表型进行特征分析,并进行生存分析与风险分层;最后,对预测模型进行验证。结果开发队列中512例存活、85例死亡,总体28 d死亡率为14.2%;验证队列中341例存活、64例死亡,总体28 d死亡率为16.3%。开发队列中死亡组PCT d3、PCT d5、PCT d7高于存活组(P<0.01);ROC曲线结果显示,PCT d7预测效能较高,ROC曲线下面积为0.833。开发队列组基轨迹建模确定了4种脓毒症亚表型:“中起点快速上升型”的特征是呼吸功能障碍;“低起点缓慢下降型”的特征是并发症及危重症评分均较低,视为基线组;“高起点快速下降型”的特征是合并症及危重症评分均较高;“高起点缓慢下降型”的特征是多器官功能障碍,危重症评分较高,视为入院时最严重组。通过对4种亚表型进行生存分析,结果显示“中起点快速上升型”死亡率最高,定义为高危组;其次为“高起点缓慢下降型”,定义为中危组;“低起点缓慢下降型”和“高起点快速下降型”死亡率较低,定义为低危组。验证队列与开发队列PCT轨迹和合并症的�
张少通王博张明瑞马桂燕柳少光
关键词:脓毒症降钙素原预后
早期中性粒细胞与淋巴细胞比值联合降钙素原在诊断重症急性胰腺炎中的价值及临床预测模型的构建
2024年
目的探讨入院时患者血清中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)及降钙素原(procalcitonin,PCT)水平对于预测重症急性胰腺炎(severe acute pancreatitis,SAP)的价值,并构建临床预测模型。方法选取安徽医科大学附属阜阳人民医院2021年9月至2022年9月收治的急性胰腺炎(acute pancreatitis,AP)患者112例,根据疾病严重程度分为SAP组(n=58)和非SAP组(n=54)。收集两组患者的一般临床资料和入院24 h内外周血实验室指标,分析SAP组与非SAP组相关危险因素并绘制森林图,使用多因素logistic回归分析筛选出独立危险因素,绘制出受试者工作特征曲线(receiver operating characteristic,ROC)并构建临床预测模型,比较不同指标的曲线下面积、敏感度和特异度。结果两组患者在入院时收缩压、住院天数、合并基础疾病(高血压)差异均存在统计学意义(均P<0.05);白细胞计数(white blood cell,WBC)、中性粒细胞计数绝对值(neutrophil,NE)、淋巴细胞计数绝对值(lymphocyte,L)、NLR、血小板-淋巴细胞比值(platelet to lymphocyte ratio,PLR)、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、高密度脂蛋白(high-density lipoprotein,HDL)、Ca^(2+)、载脂蛋白A1(apolipoprotein A1,APO A1)、载脂蛋白A2(apolipoprotein A2,APO A2)、血肌酐(serum creatinine,SCR)、白蛋白(albumin,ALB)、血糖(glucose,Glu)、C-反应蛋白(C-reaction protein,CRP)、PCT、凝血酶原时间(prothrombin time,PT)、D-二聚体(D-dimer)为AP患者病情严重有关(均P<0.05);多因素logistic回归分析显示,NLR、APO A1、APO A2、Glu和PCT是影响AP严重程度的独立危险因素(P<0.05);ROC曲线分析显示,NLR、PCT、NLR+PCT及临床模型预测AP严重程度的AUC(95%CI)分别为0.786(0.702~0.869)、0.744(0.651~0.838)、0.883(0.822~0.944)和0.964(0.096~1.000)。结论NLR和PCT是影响AP病情严重程度的独立危险因素,对其具有一定预测价值,且二者联合使用预测价值更高。
张周祥王旋宁长青
关键词:急性胰腺炎降钙素原
Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke: an over 10-year intensive care survey被引量:2
2024年
BACKGROUND:Heatstroke has become a common emergency event in hospitals.Procalcitonin(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heatstroke(EHS)remains unclear.METHODS:A retrospective cohort study enrolled patients with EHS from the intensive care unit(ICU).We collected RM biomarkers,inflammation markers,critical disease scores at admission,24 h,48 h,and discharge,and 90-day mortality.Correlation analysis,linear regression and curve fi tting were used to identify the relationship between PCT and RM.RESULTS:A total of 162 patients were recruited and divided into RM(n=56)and non-RM(n=106)groups.PCT was positively correlated with myoglobin(Mb),acute hepatic injury,disseminated intravascular coagulation(DIC),Sequential Organ Failure Assessment(SOFA)score,and Acute Physiology and Chronic Health Evaluation II(APACHE II)score,with correlation coefficients of 0.214,0.237,0.285,0.454,and 0.368,respectively(all P<0.05).Interestingly,the results of curve fi tting revealed a nonlinear relationship between PCT and RM,and a two-piecewise linear regression model showed that PCT was related to RM with an odds ratio of 1.3 and a cut-off of<4.6 ng/mL.Survival analysis revealed that RM was associated with higher mortality compared to non-RM cases(P=0.0093).CONCLUSION:High serum PCT concentrations are associated with RM after EHS in critically ill patients.Elevated PCT concentrations should be interpreted cautiously in patients with EHS in the ED.
Li ZhongFeifei ShuaiConglin WangLipeng HanZhifeng LiuMing Wu
关键词:PROCALCITONINMYOGLOBINRHABDOMYOLYSIS
Diagnostic significance of serum levels of serum amyloid A,procalcitonin,and high-mobility group box 1 in identifying necrotising enterocolitis in newborns
2024年
BACKGROUND Necrotising enterocolitis(NEC)is a critical gastrointestinal emergency affecting premature and low-birth-weight neonates.Serum amyloid A(SAA),procalcitonin(PCT),and high-mobility group box 1(HMGB1)have emerged as potential biomarkers for NEC due to their roles in inflammatory response,tissue damage,and immune regulation.AIM To evaluate the diagnostic value of SAA,PCT,and HMGB1 in the context of NEC in newborns.METHODS The study retrospectively analysed the clinical data of 48 newborns diagnosed with NEC and 50 healthy newborns admitted to the hospital.Clinical,radiological,and laboratory findings,including serum SAA,PCT,and HMGB1 Levels,were collected,and specific detection methods were used.The diagnostic value of the biomarkers was evaluated through statistical analysis,which was performed using chi-square test,t-test,correlation analysis,and receiver operating characteristic(ROC)analysis.RESULTS The study demonstrated significantly elevated levels of serum SAA,PCT,and HMGB1 Levels in newborns diagnosed with NEC compared with healthy controls.The correlation analysis indicated strong positive correlations among serum SAA,PCT,and HMGB1 Levels and the presence of NEC.ROC analysis revealed promising sensitivity and specificity for serum SAA,PCT,and HMGB1 Levels as potential diagnostic markers.The combined model of the three biomarkers demonstrating an extremely high area under the curve(0.908).CONCLUSION The diagnostic value of serum SAA,PCT,and HMGB1 Levels in NEC was highlighted.These biomarkers potentially improve the early detection,risk stratification,and clinical management of critical conditions.The findings suggest that these biomarkers may aid in timely intervention and the enhancement of outcomes for neonates affected by NEC.
Li-Ming GuoZhi-Hui JiangHong-Zhen LiuLei Zhang
关键词:PROCALCITONIN
A novel SERS platform based on flower-like Bi2WO6-GO for the quantification of sepsis-associated biomarker procalcitonin
2024年
Procalcitonin(PCT)is a promising biomarker for identification of the origin and severity of sepsis,which is a deadly body infection.However,traditional diagnostic tools exhibited challenges in complicated instruments,sensitivity and time consuming.Herein,we created a highly sensitive and selective surface-enhanced Raman scattering(SERS)platform for PCT monitoring based on flower-like Bi2WO6-graphene(Bi2WO6-GO),which was created as a chemical mechanism(CM)-based SERS substrate with high stability as well as a remarkable enhancement factor(EF)value of 2.07×10^(8).The high EF value was primarily attributed to the efficient charge transfer(CT)between Bi_(2)WO_(6)-GO and 4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en)vinyl)phenyl)boronic acid(BP)as a Raman reporter.The BP molecule was designed to play double key roles as a Raman reporter as well as a recognition probe.Owing to the specially designed BP molecule recognition of PCT and the high SERS effects of BP on Bi_(2)WO_(6)-GO,the developed SERS platform was employed for ultrasensitive and selective PCT quantification with a limit of detection down to 0.31 pg/mL in less than 8 min.The developed platform was also successfully utilized for early monitoring in sepsis rats,demonstrating practical potential for pathogene screening.
Sitong LiRui LanQing LiuYang TianTingting Zheng
关键词:SEPSISPROCALCITONINBIOSENSOR
降钙素原的临床应用研究进展
2024年
降钙素原(PCT)是一种炎症生物学标志物,被广泛用于判断感染类型及其严重程度、指导抗菌药物的合理使用,在肺部感染与血流感染方面较其他传统炎症指标优势显著。研究发现PCT在肾综合征出血热、疟疾、肿瘤性疾病、血液透析等非细菌感染性疾病患者血清中也会升高,但尚无统一的参考标准,是否合并细菌感染需结合病史、流行病学史、病原学检查进行综合评估。本文就近年来PCT在感染性疾病与非感染性疾病的临床应用进展进行综述。
何蓉会罗国平张昌艳陈星梁建英任崇松
关键词:降钙素原脓毒血症疟疾肾综合征出血热
感染性心内膜炎细胞因子和降钙素原的表达被引量:1
2024年
目的探讨感染性心内膜炎(IE)患者中12项细胞因子(IL-1β、IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、IL-12p70、IL-17、IFN-α、IFN-γ、TNF-α)及降钙素原的表达。方法纳入我院2021年12月至2022年12月IE患者10例为IE组,随机选择同期入院手术的非感染性、非风湿性瓣膜病的心内膜炎患者10例为对照组,患者均于入院时采血。采用流式细胞术检测12种细胞因子的表达及血常规指标,采用ELISA法检测降钙素原水平,采用Pearson法分析IE患者细胞因子表达水平间的相关性,Spearman法分析IE患者IL-8水平、白细胞计数与降钙素原的相关性。结果与对照组比较,IE组患者中细胞因子IL-1β、IL-2、IL-6、IL-10、TNF-α、IFN-α、IFN-γ、IL-12p70显著升高(P<0.05),白细胞计数、中性粒细胞百分比、降钙素原水平显著升高(P<0.05)。2组患者单核细胞百分比比较,差异无统计学意义(P>0.05)。IE组患者中的IFN-α与IL-2、TNF-α、IL-1β、IL-12p70呈正相关;IL-2与TNF-α、IL-1β呈正相关;IL-12p70与IFN-γ呈正相关;降钙素原与IL-8、白细胞计数呈显著正相关,差异均有统计学意义(P<0.05)。结论IE患者中IL-1β、IL-2、IL-6、IL-10、TNF-α、IFN-α、IFN-γ、IL-12p70、降钙素原等水平明显高于正常人群,这些指标的检测对于IE的早期诊断及病情严重程度的评估具有指导意义。
王若昕付亮赵金龙陈宗辉倪寅凯励峰
关键词:感染性心内膜炎细胞因子降钙素原心脏瓣膜病血常规检查
降钙素原在老年患者中应用的文献计量学分析
2024年
目的通过文献计量学分析降钙素原(PCT)在老年患者中的研究现状和焦点,为今后的相关研究提供参考。方法在PubMed数据库中搜索从数据库建立至2023年5月关于PCT与老年人的文献。随后通过书目共现软件及统计软件SPSS 22.0对论文的发文量、发文时间、国家、期刊、主题词进行统计分析。结果共检索到PCT与老年人研究现状的相关文献38篇,2017年开始有相关文献报道,文献发表总量少,由15个国家分别在28种期刊上发表,其中我国学者及杂志社发文量最多。相关文献共使用了82个主要主题词及副主题词,总出现频次为105,频次≥2被截取为高频词,共12个,而排名前5的是PCT、C-反应蛋白、尿路感染、生物标志物、细菌感染。对12个高频词进行了聚类及多维尺度分析,大致可分为3组:PCT在老年肺炎患者中的应用;PCT在老年泌尿系统感染中的研究状况;PCT与老年重症感染。结论PCT在老年患者中的研究处于发展阶段,主要应用于老年患者感染性疾病的诊断及评估。
郭伟强韦碧柳
关键词:降钙素原C-反应蛋白尿路感染文献计量学
降钙素原在化脓性脊柱炎中的诊断价值分析
2024年
目的探讨降钙素原(PCT)对化脓性脊柱炎(PS)的诊断价值。方法收集2022年1月至2023年12月我院确诊的PS患者96例(A组)、脊柱结核(TBS)91例(B组)及骨质疏松性压缩骨折(OVCF)100例(C组)的PCT、C反应蛋白(CRP)、红细胞沉降率(ESR)检测结果,比较三者分别与联合检测对PS、TBS、OVCF诊断敏感度和特异性。计算ROC曲线下面积(AUC),评估三者分别与联合对化脓性脊柱炎的诊断价值。结果C组的发病年龄明显大于A、B组(P<0.05),A与B组之间发病年龄差异无统计学意义(P>0.05);三组PCT、CRP及ESR检测值均数比较差异有统计学意义(P<0.05),均为A组>B组>C组。A组的PCT、CRP、ESR特异度为77.5%、64.4%、57.1%、联合诊断82.7%,敏感度为80.2%、88.5%、88.5%、联合诊断94.7%,AUC分别为0.820、0.720、0.779、联合诊断0.804,均有诊断价值(AUC>0.5),其中,PCT>ESR、PCT>CRP、三者联合>CRP(P<0.05),ESR与CRP、PCT与三者联合、ESR与三者联合之间差异无统计学意义(P>0.05)。B组PCT、CRP、ESR的特异度为59.2%、51.0%、49.0%、联合诊断75.2%,敏感度为43.9%、62.6%、73.6%、联合诊断81.3%,AUC分别为0.740、0.664、0.624、联合诊断0.663,均有诊断价值(AUC>0.5),其中,PCT>ESR、PCT>CRP、PCT>三者联合(P<0.05),ESR与CRP、三者联合与ESR、三者联合与CRP之间差异无统计学意义(P>0.05)。结论(1)PCT、CRP、ESR及三者联合在诊断PS均具有一定的临床价值,PCT和PCT联合CRP、ESR对PS诊断的特异性优于CRP、ESR。(2)PCT和PCT联合CRP、ESR对PS鉴别TBS及OVCF均有较高的诊断效能。
包羽生雷飞周庆忠冯大雄
关键词:化脓性脊柱炎脊柱结核骨质疏松性压缩骨折C反应蛋白红细胞沉降率降钙素原

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