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河北农业大学生命科学学院制药工程系

作品数:2 被引量:1H指数:1
发文基金:国家自然科学基金更多>>
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严格厌氧大豆异黄酮转化菌株的耐氧驯化与有氧转化调控
迄今国内外报道的大豆异黄酮转化菌均必须在严格厌氧条件下才能完成转化功能.2011年我们将严格厌氧牛瘤胃细菌菌株Sharpea sp.strain Niu-016首次成功驯化为耐氧突变株Aeroto-Niu-016,该耐氧...
王秀伶
Bioconversion of genistein to(–)-5-hydroxy-equol by a newly isolated cock intestinal anaerobic bacterium被引量:1
2015年
A newly isolated bacterium, named as AUH-JLC257, was found to be capable of bioconverting isoflavone genistein to 5-hydroxy-equol under anaerobic conditions. The metabolite 5-hydroxy-equol was identified by using UV spectrum, electrospray ionization mass spectrometry (ESI-MS) as well as IH and 13C NMR analyses. Chiral stationary-phase high-performance liquid chromatography analysis and specific rotation examination demonstrated that the bio-synthesized 5-hydroxy-equol was just (-)-5-hydroxy-equol. The average bioconverting rate was 83.1%, and the strain AUH-JLC257 could efficiently transform genistein at a maximal substrate concentration of 0.6 mmol/L. We, for the first time, showed that the bio-synthesized 5-hydroxy-equol had 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity at concentrations as low as 3.3μmol/L. In addition, the 16S rRNA gene sequence (1401 bp) of the bacterium strain AUH-JLC257 showed the highest similarity (99.27%) to that of Slackia equolifaciens strain DZE.
谢雁景刘子光高雅宁王秀伶郝庆红于秀梅
关键词:GENISTEIN
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