The reduction of diaryldiselenides by Cp2TiCl2/BuiMgBr/THF led to arylselenium complex of titanocene [Cp2TiSeAr]. This species reacted smoothly with electrophilic substrates such as acylhalides, α-bromocarbonyl compounds, diaryliodonium salts, α,β-unsaturated carbonyl compounds to afford the corresponding organic selenides in high yields.
N 1-(2-Fursnidyl)-5-fluorouracil reacted with multimethylenes chlorohydrin in the presence of NaHCO3 in acetonitrile at 80 ℃ to give N 1-(2-furanidyl)-N 3-(hydroxyalkyl)-5-fulorouracils in a high yield (≥93%). Their cyclic glycerophospholipid conjugates were synthesized and had a good activity against the man urinary bladder cancer cell in vitro.